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Title: Unorthodox crystalline drug salts via the reaction of amine-containing drugs with CO 2
Drugs containing amine groups react with CO 2 to form crystalline ammonium carbamates or carbamic acids. In this approach, both the cation and anion of the salt, or the neutral CO 2 adduct, are derived from the parent drug, generating new crystalline versions in a ‘masked’ or prodrug form. It is proposed that this approach may serve as a valuable new tool in engineering the physical properties of drugs for formulation purposes.  more » « less
Award ID(s):
1800122
PAR ID:
10167998
Author(s) / Creator(s):
; ; ; ; ; ; ; ;
Date Published:
Journal Name:
Chemical Communications
Volume:
55
Issue:
90
ISSN:
1359-7345
Page Range / eLocation ID:
13546 to 13549
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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