More Like this

1. Asymmetric mitochondrial trafficking balances perinuclear biogenesis to maintain network morphology

   https://doi.org/10.1083/jcb.202409118  

   Winter, Julius; Landoni, Juan C; Holt, Keaton B; Ben_Nejma, Sheda; Durmus, Emine Berna; Kleele, Tatjana; Koslover, Elena F; Manley, Suliana (August 2026, Journal of Cell Biology)

   In functionally polarized cells, mitochondria can form distinct subpopulations, positioned at sites of varying metabolic and energetic demands. Thus far, the potential presence of such subpopulations and implications of their intracellular trafficking in immobile and proliferative cells remain largely undescribed, despite such cells serving as key models. Here, we use substrate micropatterning to create reproducible morphologies of cultured immortalized cells, enabling us to define mitochondrial subpopulations and follow their trafficking by photoactivation. We discovered that mitochondrial material is dispersed asymmetrically throughout the cell via biased anterograde transport from the perinuclear area. Combining quantitative analysis and in silico modeling, we characterize the causes and consequences of unbalanced mitochondrial trafficking. Our findings indicate that this bias is required to distribute new material resulting from perinuclear mitochondrial biosynthesis to sustain mitochondrial mass distribution across the cell and to maintain normal network connectivity. 

   more » « less
2. Multimodal data fusion of cortical-subcortical morphology and functional network connectivity in psychotic spectrum disorder

   https://doi.org/10.1016/j.nicl.2022.103056  

   DeRamus, TP; Wu, L; Qi, S; Iraji, A; Silva, R; Du, Y; Pearlson, G; Mayer, A; Bustillo, JR; Stromberg, SF; et al (January 2022, NeuroImage: Clinical)
3. Analyzing the Morphology of the Neurovascular Network through Two-Photon Imaging Over time

   Lopez-Valdez, D; Mihelic, S; Englemann, S; Zhou, A; Dunn, A (January 2021, Biomedical Engineering Society annual meeting)
4. Dynamic Musculoskeletal Functional Morphology: Integrating diceCT and XROMM: DYNAMIC FUNCTIONAL MORPHOLOGY

   https://doi.org/10.1002/ar.23714  

   Orsbon, Courtney P.; Gidmark, Nicholas J.; Ross, Callum F. (February 2018, The Anatomical Record)
5. The spatial structure of variation in salamander survival, body condition and morphology in a headwater stream network

   https://doi.org/10.1111/fwb.13133  

   Lowe, Winsor H.; Addis, Brett R.; Smith, Margaret R.; Davenport, Jon M. (October 2018, Freshwater Biology)