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1. A general Ca-MOM platform with enhanced acid-base stability for enzyme biocatalysis

   https://doi.org/https://doi.org/10.1016/j.checat.2021.03.001  

   Pan, Y.; Li, Q.; Li, H.; Farmakes, J.; Ugrinov, A.; Zhu, X.; Lai, Z.; Chen, B.; Yang, Z. (April 2021, Chem catalysis)

   null (Ed.)

   Co-precipitation of enzymes in metal-organic frameworks is a unique enzyme-immobilization strategy but is challenged by weak acid-base stability. To overcome this drawback, we discovered that Ca2+ can co-precipitate with carboxylate ligands and enzymes under ambient aqueous conditions and form enzyme@metal-organic material composites stable under a wide range of pHs (3.7–9.5). We proved this strategy on four enzymes with varied isoelectric points, molecular weights, and substrate sizes—lysozyme, lipase, glucose oxidase (GOx), and horseradish peroxidase (HRP)—as well as the cluster of HRP and GOx. Interestingly, the catalytic efficiency of the studied enzymes was found to depend on the ligand, probing the origins of which resulted in a correlation among enzyme backbone dynamics, ligand selection, and catalytic efficiency. Our approach resolved the long-lasting stability issue of aqueous-phase co-precipitation and can be generalized to biocatalysis with other enzymes to benefit both research and industry. 

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2. The drivers and consequences of unstable Plasmodium dynamics: a long-term study of three malaria parasite species infecting a tropical lizard

   https://doi.org/10.1017/S0031182018001750  

   Otero, Luisa; Schall, Jos J.; Cruz, Virnaliz; Aaltonen, Kristen; Acevedo, Miguel A. (April 2019, Parasitology)

   Abstract Understanding the consequences of environmental fluctuations for parasite dynamics requires a long-term view stretching over many transmission cycles. Here we studied the dynamics of three malaria parasites ( Plasmodium azurophilum , P. leucocytica and P. floridense ) infecting the lizard Anolis gundlachi , in the rainforest of Puerto Rico. In this malaria–anole system we evaluated temporal fluctuations in individual probability of infection, the environmental drivers of observed variation and consequences for host body condition and Plasmodium parasites assemblage. We conducted a total of 15 surveys including 10 from 1990 to 2002 and five from 2015 to 2017. During the early years, a lizard's probability of infection by all Plasmodium species appeared stable despite disturbances ranging from two hurricanes to short droughts. Over a longer timescale, probability of infection and overall prevalence varied significantly, following non-linear relationships with temperature and rainfall such that highest prevalence is expected at intermediate climate measures. A perplexing result was that host body condition was maximized at intermediate levels of rainfall and/or temperature (when risk of infection was highest), yet we found no significant decreases in body condition due to infection. Plasmodium parasite species composition varied through time with a reduction and near local extinction of P. floridense . Our results emphasize the need for long-term studies to reveal host–parasite dynamics, their drivers and consequences. 

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3. Photoinduced modification of optical properties of ferroelectric PZT thin films

   https://doi.org/10.1557/s43579-023-00476-6  

   Yousefi, Saeed; Hua, Nelson; Mehta, Jugal; Li, Jianheng; Guillemot, Loïc; Rippy, Geoffery; Zhong, Louie; Schaller, Richard_D; Maroutian, Thomas; Haldrup, Kristoffer; et al (October 2023, MRS Communications)

   Abstract This study investigates ultrafast photoinduced changes in optical properties of ferroelectrics (PZT) on femtosecond to nanosecond timescales, using broadband transient reflectivity studies. Surprisingly, spectral features were observed below the bandgap, which could not be attributed to ground state bleaching, excited state absorption, and/or stimulated emission. A model based on probe energy independent changes in refractive index and extinction coefficient showed good agreement with experimental results. Three relaxation processes were phenomenologically considered for the temporal evolution. Laser-induced heating was ruled out as the cause of short timescale behavior and photorefractive effect was suggested as a potential mechanism for changes in the optical properties. Graphical abstract 

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4. Timescales of Dike Growth and Chamber Deflation Constrain Magma Storage and Transport Pathways During Kīlauea's 2018 Lower East Rift Zone Intrusion

   https://doi.org/10.1029/2022JB025636  

   Townsend, Meredith; Huang, Mong‐Han (December 2022, Journal of Geophysical Research: Solid Earth)

   Abstract The intrusion of magma into Kīlauea's lower East Rift Zone in May 2018 led to the largest eruption along this segment of the volcano in over 200 years. As magma drained from the rift zone, leading to the collapse of Pu'u ‘Ō‘ō, pressure at the summit initially remained elevated and dropped at a slower rate compared to historical intrusion events. The anomalously long timescale of summit deflation suggests that the dike was fed from multiple sources. Here we show that dikes can serve as “dipsticks” of magma reservoirs and that the co‐evolution of dike growth and reservoir deflation constrains key magma transport parameters. Using coupled dike‐chamber models constrained by ground deformation and seismicity, we test four configurations of magma plumbing in order to illuminate which reservoirs and transport pathways were activated during the intrusion phase (30 April to 3 May) of the 2018 event. Slow summit deflation relative to the rate of dike propagation is best explained by a model in which the dike initiates from a compressible magma reservoir in the East Rift Zone, which then drains magma upstream from the Halema'uma'u reservoir through a shallow transport system. We use a Bayesian Markov chain Monte Carlo (MCMC) approach to estimate storage parameters for both reservoirs as well as the effective conductivity of the shallow magma transport system in the East Rift Zone, finding good agreement with independent estimates. Our results suggest that the rupture of reservoirs from within the East Rift Zone presents a unique hazard at Kīlauea. 

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5. Paris Agreement's Ambiguity About Aerosols Drives Uncertain Health and Climate Outcomes

   https://doi.org/10.1029/2020EF001787  

   Polonik, Pascal; Ricke, Katharine; Burney, Jennifer (May 2021, Earth's Future)

   Abstract Anthropogenic aerosols are hazardous to human health but have helped offset warming from greenhouse gases (GHGs), creating a potential regulatory tradeoff. As countries implement their GHG reduction targets under the Paris climate agreement, the co‐emissions of aerosols and their precursors will also change. Since these co‐emissions vary by country and by economic sector, each country will face different tradeoffs between aerosol‐driven health or temperature co‐benefits. We combine simple parameterizations of physical processes and health outcomes to examine three idealized climate policy approaches that are consistent with the Paris Agreement targets, which (i) optimize for local air quality, (ii) reduce global temperature change, or (iii) reduce emissions equally from all domestic economic sectors. We evaluate aerosol impacts on premature mortality and global mean temperature change under these three policy approaches and find that by 2030 the three policies yield differences of over 1 million annual premature deaths and global temperature differences of the same magnitude as those from GHG reductions. We also show that implementing equal reductions between all economic sectors can actually result in less beneficial health and temperature outcomes than either of the other options, especially in less industrialized regions. We therefore conclude that aerosol‐related co‐benefits and aerosol accounting guidelines should be explicitly considered in setting international climate policy. 

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