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1. Synthesis of Unsaturated Silyl Heterocycles via an Intramolecular Silyl-Heck Reaction

   https://doi.org/10.1021/acs.organomet.9b00498  

   Reid, William B.; McAtee, Jesse R.; Watson, Donald A. (September 2019, Organometallics)
2. An Experimental Stereoselective Photochemical [1s,3s]-Sigmatropic Silyl Shift and the Existence of Silyl/Allyl Conical Intersections

   https://doi.org/10.1021/jacs.9b11579  

   Hammer, Niels; Christensen, Mette Louise; Chen, Yu; Naharro, Daniel; Liu, Fang; Jørgensen, Karl Anker; Houk, K. N. (April 2020, Journal of the American Chemical Society)
3. Electrophilic heterocycles: Functionalization with enol silyl ethers

   https://doi.org/10.1016/j.tet.2023.133511  

   Holmin, Grant P.; Hood, Jacob C.; Xue, Hongfang; Klumpp, Douglas A. (August 2023, Tetrahedron)
4. Biocatalytic, stereoconvergent alkylation of (Z/E)-trisubstituted silyl enol ethers

   https://doi.org/10.1038/s44160-023-00431-2  

   Mao, Runze; Taylor, Doris Mia; Wackelin, Daniel J.; Rogge, Torben; Wu, Sophia J.; Sicinski, Kathleen M.; Houk, K. N.; Arnold, Frances H. (February 2024, Nature Synthesis)

   The selective conversion of mixtures of Z/E alkenes into chiral products is a synthetic challenge. Biocatalytic strategies can transform isomeric alkenes into stereopure compounds, but enzymes typically convert only one alkene isomer, thereby limiting the overall yield. Additional strategies have been used to interconvert alkene isomers, often at the cost of increasing energy consumption and chemical waste. Here, we present engineered hemoproteins derived from a bacterial cytochrome P450 that efficiently catalyze α-carbonyl alkylation of isomeric silyl enol ethers, producing stereopure products. Through screening and directed evolution, we generated P450BM3 variant P411-SCA-5188, which catalyzes stereoconvergent carbene transfer in Escherichia coli with high efficiency and stereoselectivity to various Z/E mixtures of silyl enol ethers. In contrast to established stereospecific transformations that leave one isomer unreacted, P411-SCA-5188 converts both isomers to a stereopure product. This biocatalytic approach simplifies the synthesis of chiral α-branched ketones by eliminating the need for stoichiometric chiral auxiliaries, strongly basic alkali-metal enolates, and harsh conditions, delivering products with high efficiency and excellent chemo- and stereoselectivities. 

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5. Synthesis and Reactivity of Pincer-Type Cobalt Silyl and Silylene Complexes

   https://doi.org/10.1021/acs.organomet.8b00594  

   Zhang, Jia; Foley, Bryan J.; Bhuvanesh, Nattamai; Zhou, Jia; Janzen, Daron E.; Whited, Matthew T.; Ozerov, Oleg V. (October 2018, Organometallics)