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  • Integrating Ion Mobility and Imaging Mass Spectrometry for Comprehensive Analysis of Biological Tissues: A brief review and perspective
Title: Integrating Ion Mobility and Imaging Mass Spectrometry for Comprehensive Analysis of Biological Tissues: A brief review and perspective
Imaging mass spectrometry (IMS) technologies are capable of mapping a wide array of biomolecules in diverse cellular and tissue environments. IMS has emerged as an essential tool for providing spatially targeted molecular information due to its high sensitivity, wide molecular coverage and chemical specificity. One of the major challenges for mapping the complex cellular milieu is the presence of many isomers and isobars present in these samples. This challenge is traditionally addressed using orthogonal LC-based analysis, though, common approaches such as chromatography and electrophoresis are not able to be performed at timescales that are compatible with most imaging applications. Ion mobility offers rapid, gas-phase separations that are readily integrated with IMS workflows in order to provide additional data dimensionality that can improve signal-to-noise, dynamic range, and specificity. Here, we highlight recent examples of ion mobility coupled to imaging mass spectrometry and highlight their importance to the field.  more » « less
Award ID(s):
1828299
PAR ID:
10184247
Author(s) / Creator(s):
; ; ; ;
Date Published:
Journal Name:
Journal of Mass Spectrometry
ISSN:
1076-5174
Page Range / eLocation ID:
e4614
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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