Rapid urbanization has posed significant burden on urban transportation infrastructures. In today's cities, both private and public transits have clear limitations to fulfill passengers' needs for quality of experience (QoE): Public transits operate along fixed routes with long wait time and total transit time; Private transits, such as taxis, private shuttles and ride-hailing services, provide point-to-point transits with high trip fare. In this paper, we propose CityLines, a transformative urban transit system, employing hybrid hub-and-spoke transit model with shared shuttles. Analogous to Airlines services, the proposed CityLines system routes urban trips among spokes through a few hubs or direct paths, with travel time as short as private transits and fare as low as public transits. CityLines allows both point-to-point connection to improve the passenger QoE, and hub-and-spoke connection to reduce the system operation cost. Our evaluation results show that CityLines framework can achieve both short travel time and high ride-sharing ratio.
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SAT-Hub: Smart and Accessible Transportation Hub for Assistive Navigation and Facility Management.
The goal of the proposed project is to transform a large transportation hub into a smart and accessible hub (SAT-Hub), with minimal infrastructure change. The societal need is significant, especially impactful for people in great need, such as those who are blind and visually impaired (BVI) or with Autism Spectrum Disorder (ASD), as well as those unfamiliar with metropolitan areas. With our inter-disciplinary background in urban systems, sensing, AI and data analytics, accessibility, and paratransit and assistive services, our solution is a hu-man-centric system approach that integrates facility modeling, mobile navigation, and user interface designs. We leverage several transportation facili-ties in the heart of New York City and throughout the State of New Jersey as testbeds for ensuring the relevance of the research and a smooth transition to real world applications.
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- NSF-PAR ID:
- 10185779
- Date Published:
- Journal Name:
- Harvard CRCS Workshop on AI for Social Good
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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We present Peekaboo, a new privacy-sensitive architecture for smart homes that leverages an in-home hub to pre-process and minimize outgoing data in a structured and enforceable manner before sending it to external cloud servers. Peekaboo’s key innovations are (1) abstracting common data preprocessing functionality into a small and fixed set of chainable operators, and (2) requiring that developers explicitly declare desired data collection behaviors (e.g., data granularity, destinations, conditions) in an application manifest, which also specifies how the operators are chained together. Given a manifest, Peekaboo assembles and executes a pre-processing pipeline using operators pre-loaded on the hub. In doing so, developers can collect smart home data on a need-to-know basis; third-party auditors can verify data collection behaviors; and the hub itself can offer a number of centralized privacy features to users across apps and devices, without additional effort from app developers. We present the design and implementation of Peekaboo, along with an evaluation of its coverage of smart home scenarios, system performance, data minimization, and example built-in privacy features.more » « less
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Rapid urbanization has posed significant burden on urban transportation infrastructures. In today's cities, both private and public transits have clear limitations to fulfill passengers' needs for quality of experience (QoE): Public transits operate along fixed routes with long wait time and total transit time; Private transits, such as taxis, private shuttles and ride-hailing services, provide point-to-point transits with high trip fare. In this paper, we propose CityLines, a transformative urban transit system, employing hybrid hub-and-spoke transit model with shared shuttles. Analogous to Airlines services, the proposed CityLines system routes urban trips among spokes through a few hubs or direct paths, with travel time as short as private transits and fare as low as public transits. CityLines allows both point-to-point connection to improve the passenger QoE, and hub-and-spoke connection to reduce the system operation cost. To evaluate the performance of CityLines, we conduct extensive data-driven experiments using one-month real-world trip demand data (from taxis, buses and subway trains) collected from Shenzhen, China. The results demonstrate that CityLines reduces 12.5%-44% average travel time, and aggregates 8.5%-32.6% more trips with ride-sharing over other implementation baselines.more » « less
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It has been evident that N6-methyladenosine (m6A)-modified long noncoding RNAs (m6A-lncRNAs) involves regulating tumorigenesis, invasion, and metastasis for various cancer types. In this study, we sought to pick computationally up a set of 13 hub m6A-lncRNAs in light of three state-of-the-art tools WGCNA, iWGCNA, and oCEM, and interrogated their prognostic values in brain low-grade gliomas (LGG). Of the 13 hub m6A-lncRNAs, we further detected three hub m6A-lncRNAs as independent prognostic risk factors, including HOXB-AS1, ELOA-AS1, and FLG-AS1 . Then, the m6ALncSig model was built based on these three hub m6A-lncRNAs. Patients with LGG next were divided into two groups, high- and low-risk, based on the median m6ALncSig score. As predicted, the high-risk group was more significantly related to mortality. The prognostic signature of m6ALncSig was validated using internal and external cohorts. In summary, our work introduces a high-confidence prognostic prediction signature and paves the way for using m6A-lncRNAs in the signature as new targets for treatment of LGG.more » « less
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Abstract Motivation Joint reconstruction of multiple gene regulatory networks (GRNs) using gene expression data from multiple tissues/conditions is very important for understanding common and tissue/condition-specific regulation. However, there are currently no computational models and methods available for directly constructing such multiple GRNs that not only share some common hub genes but also possess tissue/condition-specific regulatory edges.
Results In this paper, we proposed a new graphic Gaussian model for joint reconstruction of multiple gene regulatory networks (JRmGRN), which highlighted hub genes, using gene expression data from several tissues/conditions. Under the framework of Gaussian graphical model, JRmGRN method constructs the GRNs through maximizing a penalized log likelihood function. We formulated it as a convex optimization problem, and then solved it with an alternating direction method of multipliers (ADMM) algorithm. The performance of JRmGRN was first evaluated with synthetic data and the results showed that JRmGRN outperformed several other methods for reconstruction of GRNs. We also applied our method to real Arabidopsis thaliana RNA-seq data from two light regime conditions in comparison with other methods, and both common hub genes and some conditions-specific hub genes were identified with higher accuracy and precision.
Availability and implementation JRmGRN is available as a R program from: https://github.com/wenpingd.
Supplementary information Supplementary data are available at Bioinformatics online.
- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
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- The DOI is not currently available.
