Hydrophobically-modified silica-coated gold nanorods are presented here as multifunctional theranostic agents. A single modification both increases two-photon fluorescence and promotes cavitation-based acoustic signal for imaging. A two-fold greater release of small molecule drugs was observed under ultrasound-mediated conditions as compared to passive release without ultrasound. 
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                            Protein biomaterials for theranostic applications
                        
                    
    
            Protein biomaterials have been used for a wide range biomedical applications due to their intrinsic biocompatibility, versatility and higher order structure. Multifunctional theranostic agents fabricated by incorporating the diagnostic modalities and drug payloads in protein nanoformulations have garnered significant attention in recent years. Protein-based theranostic agents manifest high target specificity, enhanced blood circulation and reduce reticuloendothelial system elimination. This review focuses on the fabrication of peptide- and protein-based nanoformulations for imaging guided therapy. 
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                            - Award ID(s):
- 1728858
- PAR ID:
- 10189474
- Date Published:
- Journal Name:
- Molecular Systems Design & Engineering
- Volume:
- 4
- Issue:
- 6
- ISSN:
- 2058-9689
- Page Range / eLocation ID:
- 1074 to 1094
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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