More Like this

1. 2D Nanoclay for Biomedical Applications: Regenerative Medicine, Therapeutic Delivery, and Additive Manufacturing

   https://doi.org/10.1002/adma.201900332  

   Gaharwar, Akhilesh_K; Cross, Lauren_M; Peak, Charles_W; Gold, Karli; Carrow, James_K; Brokesh, Anna; Singh, Kanwar_Abhay (April 2019, Advanced Materials)

   Abstract Clay nanomaterials are an emerging class of 2D biomaterials of interest due to their atomically thin layered structure, charged characteristics, and well‐defined composition. Synthetic nanoclays are plate‐like polyions composed of simple or complex salts of silicic acids with a heterogeneous charge distribution and patchy interactions. Due to their biocompatible characteristics, unique shape, high surface‐to‐volume ratio, and charge, nanoclays are investigated for various biomedical applications. Here, a critical overview of the physical, chemical, and physiological interactions of nanoclay with biological moieties, including cells, proteins, and polymers, is provided. The state‐of‐the‐art biomedical applications of 2D nanoclay in regenerative medicine, therapeutic delivery, and additive manufacturing are reviewed. In addition, recent developments that are shaping this emerging field are discussed and promising new research directions for 2D nanoclay‐based biomaterials are identified. 

   more » « less
2. Biomanufacturing in low Earth orbit for regenerative medicine

   https://doi.org/10.1016/j.stemcr.2021.12.001  

   Sharma, Arun; Clemens, Rachel A.; Garcia, Orquidea; Taylor, D. Lansing; Wagner, Nicole L.; Shepard, Kelly A.; Gupta, Anjali; Malany, Siobhan; Grodzinsky, Alan J.; Kearns-Jonker, Mary; et al (January 2022, Stem Cell Reports)
3. Recommendations for workforce development in regenerative medicine biomanufacturing

   https://doi.org/10.1002/sctm.21-0037  

   Green, Gary M.; Read, Russ H.; Lee, Sengyong; Tubon, Thomas; Hunsberger, Joshua G.; Atala, Anthony (October 2021, STEM CELLS Translational Medicine)

   null (Ed.)
4. Cell transplantation-based regenerative medicine in liver diseases

   https://doi.org/10.1016/j.stemcr.2023.06.005  

   Cardinale, Vincenzo; Lanthier, Nicolas; Baptista, Pedro M; Carpino, Guido; Carnevale, Gianluca; Orlando, Giuseppe; Angelico, Roberta; Manzia, Tommaso Maria; Schuppan, Detlef; Pinzani, Massimo; et al (August 2023, Stem Cell Reports)
5. Transcriptome-Powered Pluripotent Stem Cell Differentiation for Regenerative Medicine

   https://doi.org/10.3390/cells12101442  

   Ogi, Derek A.; Jin, Sha (May 2023, Cells)

   Pluripotent stem cells are endless sources for in vitro engineering human tissues for regenerative medicine. Extensive studies have demonstrated that transcription factors are the key to stem cell lineage commitment and differentiation efficacy. As the transcription factor profile varies depending on the cell type, global transcriptome analysis through RNA sequencing (RNAseq) has been a powerful tool for measuring and characterizing the success of stem cell differentiation. RNAseq has been utilized to comprehend how gene expression changes as cells differentiate and provide a guide to inducing cellular differentiation based on promoting the expression of specific genes. It has also been utilized to determine the specific cell type. This review highlights RNAseq techniques, tools for RNAseq data interpretation, RNAseq data analytic methods and their utilities, and transcriptomics-enabled human stem cell differentiation. In addition, the review outlines the potential benefits of the transcriptomics-aided discovery of intrinsic factors influencing stem cell lineage commitment, transcriptomics applied to disease physiology studies using patients’ induced pluripotent stem cell (iPSC)-derived cells for regenerative medicine, and the future outlook on the technology and its implementation. 

   more » « less