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Title: The Synaptic Vesicle Cycle Revisited: New Insights into the Modes and Mechanisms
Neurotransmission is sustained by endocytosis and refilling of synaptic vesicles (SVs) locally within the presynapse. Until recently, a consensus formed that after exocytosis, SVs are recovered by either fusion pore closure (kiss-and-run) or clathrin-mediated endocytosis directly from the plasma membrane. However, recent data have revealed that SV formation is more complex than previously envisaged. For example, two additional recycling pathways have been discovered, ultrafast endocytosis and activity-dependent bulk endocytosis, in which SVs are regenerated from the internalized membrane and synaptic endosomes. Furthermore, these diverse modes of endocytosis appear to influence both the molecular composition and subsequent physiological role of individual SVs. In addition, previously unknown complexity in SV refilling and reclustering has been revealed. This review presents a modern view of the SV life cycle and discusses how neuronal subtype, physiological temperature, and individual activity patterns can recruit different endocytic modes to generate new SVs and sculpt subsequent presynaptic performance.  more » « less
Award ID(s):
1727260
PAR ID:
10190503
Author(s) / Creator(s):
; ; ; ;
Date Published:
Journal Name:
The journal of neuroscience
Volume:
39
Issue:
42
ISSN:
0270-6474
Page Range / eLocation ID:
8209-8216
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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