Abstract We report the oxidative dimerization reaction of siloxydienes derived from simple enones that creates a new gamma‐gamma (γ‐γ) C−C bond using catalytic iron and benzoyl peroxide as the terminal oxidant in acetonitrile solvent at ambient temperature. The reaction shows a broad substrate scope including cyclic and acyclic siloxydienes derived from ketones, aldehydes, and esters, which are converted to 1,8‐dicarbonyl compounds under mild catalytic reaction conditions in 19–89 % yield across 30 examples. The method is suitable for the coupling of sterically demanding carbon centers, including the formation of vicinal quaternary centers. Conceptually, the dienol ether serves as a precursor to a conjugated radical cation, which undergoes highly site selective γ‐dimerization reactions. The γ‐γ dimerization strategy is applied to the synthesis of a bioactive analogue of honokiol.
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Deformation mechanisms of gamma'/gamma" co-precipitates in IN718
- Award ID(s):
- 1922239
- PAR ID:
- 10191750
- Date Published:
- Journal Name:
- Superalloys 2020
- Volume:
- 2020
- Page Range / eLocation ID:
- 669-679
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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