Cardiac myosin binding protein-C (cMyBP-C) is a thick filament protein that influences sarcomere stiffness and modulates cardiac contraction-relaxation through its phosphorylation. Phosphorylation of cMyBP-C and ablation of cMyBP-C have been shown to increase the rate of MgADP release in the acto-myosin cross-bridge cycle in the intact sarcomere. The influence of cMyBP-C on Pi-dependent myosin kinetics has not yet been examined. We investigated the effect of cMyBP-C, and its phosphorylation, on myosin kinetics in demembranated papillary muscle strips bearing the β-cardiac myosin isoform from nontransgenic and homozygous transgenic mice lacking cMyBP-C. We used quick stretch and stochastic length-perturbation analysis to characterizemore »
Automated segmentation of cardiac chambers from cine cardiac MRI using an adversarial network architecture
- Award ID(s):
- 1808530
- Publication Date:
- NSF-PAR ID:
- 10194340
- Journal Name:
- Proc. SPIE Medical Imaging – Image-guided Procedures, Robotic Interventions and Modeling
- Volume:
- 11315
- Page Range or eLocation-ID:
- 113152Y-1-6
- Sponsoring Org:
- National Science Foundation