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Abstract For many years methodological constraints limited insights on the molecular biology of non-model organisms. However, the development of various sequencing platforms has led to an explosion of transcriptomic and genomic data on non-model systems. As a consequence the molecular drivers of organismal phenotypes are becoming clearer and the chemicals that animals use to detect and respond to their environments are increasingly being revealed—this latter area inspired our symposium theme. The papers in this volume broadly address this theme by their more specific focus in one of the following general areas: 1) sensory biology and the molecular basis of perception, 2) chemicals deployed to deal with the biotic and abiotic environment, and 3) chemical interactions along the parasite–mutualist continuum. Here we outline and synthesize the content of these papers—an exercise which demonstrates that sophisticated gene repertoires enable early diverging metazoans to encode many of the signaling, sensory, defensive, and offensive capacities typically associated with animals that have complex nervous systems. We then consider opportunities and associated challenges that may delay progress in comparative functional biochemistry, a reinvigorated field that can be expected to rapidly expand with new ’omics data. Future knowledge of chemical adaptations should afford new perspectives on the comparative evolution of chemical mediators.
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Building Bridges from Genome to Phenome: Molecules, Methods and Models—An Introduction to the Symposium
Synopsis How stable genotypes interact with their environment to generate phenotypic variation that can be acted upon by evolutionary and ecological forces is a central focus of research across many scientific disciplines represented within SICB. The Building Bridges Symposium brought together scientists using a variety of organisms, methods, and levels of biological organization to study the emergent properties of genomes. Workshops associated with the Symposium aimed to identify the leading edges and major barriers to research in this field, and to recommend future directions that might accelerate the pace of progress. The papers included in this Symposium volume draw attention to the strength of using comparative approaches in non-model organisms to study the many aspects of genotype–environment interaction that drive phenotype variation. These contributions and the concluding white paper also illustrate the need for novel conceptual frameworks that can bridge and accommodate data and conclusions from the broad range of study systems employed by comparative and integrative biologists to address genome-to-phenome questions.
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- Award ID(s):
- 1927470
- PAR ID:
- 10196249
- Date Published:
- Journal Name:
- Integrative and Comparative Biology
- Volume:
- 60
- Issue:
- 2
- ISSN:
- 1540-7063
- Page Range / eLocation ID:
- 261 to 266
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1093/icb/icaa073
