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Title: The penetration and movement of nanoparticles on membrane
In this study, we used GROMACS, a versatile package for performing molecular dynamics to simulate the interactions between different nanoparticles and Dipalmitoyl Phosphatidyl Choline (DPPC) to understand the physical mechanisms that govern the interactions between nanoparticles and lipid membrane. Our simulations show the responses of the lipid bilayer to the nanoparticles, including the formation of an adsorbent layer on the nanoparticle surface, transmembrane ectopic movements, and inconspicuous endocytosis of the nanoparticle by the membrane. The effects of the size of the nanoparticles, structural shape, and charge state on the interaction and transport processes will be examined and summarized.  more » « less
Award ID(s):
1833015
PAR ID:
10199994
Author(s) / Creator(s):
; ; ; ; ; ;
Editor(s):
Achilefu, Samuel; Raghavachari, Ramesh
Date Published:
Journal Name:
Nanoparticles, and Molecular Probes for Biomedical Applications XII
Volume:
1052621
Page Range / eLocation ID:
M1-M11
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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