More Like this

1. Synthesis and Antibacterial Activity of Ficuseptine and Its Derivatives: Determination of Structure–Activity Relationships

   https://doi.org/10.1055/a-2490-2986  

   Hoang, Nghia_L T; Nsereko, Nina_N P; Sheetz, Sydney A; Tasker, Sarah Z (April 2025, Synlett)

   Abstract The indolizinium natural product ficuseptine, produced by the tropical fig tree Ficus septica, has been reported to have antibacterial properties. Herein, the synthesis of ficuseptine, ten analogues with differing aryl substituents, and two aryl regioisomers is reported. Despite several previous total syntheses, synthetically prepared ficuseptine has not been subjected to biological testing to confirm its activity. In our hands, ficuseptine was moderately active in Gram-positive B. spizizenii, with an MIC of 32 μg/mL, which was maintained for most aryl substituents. The position of the aryl rings was crucial, however, since regioisomeric ficuseptine analogues, mimicking related natural products, were found to be inactive. Finally, all ficuseptine derivatives were inactive (MIC >128 μg/mL) against Gram-negative E. coli. Understanding these structure–activity relationships (SAR) is helpful for future studies to understand the molecule’s mechanism of action or further develop its antibacterial properties. 

   more » « less
2. Synthesis, characterization, and anticancer activity of Schiff bases

   https://doi.org/10.1080/07391102.2019.1654924  

   Uddin, Noor; Rashid, Faisal; Ali, Saqib; Tirmizi, Syed Ahmed; Ahmad, Iqbal; Zaib, Sumera; Zubair, Muhammad; Diaconescu, Paula L.; Tahir, Muhammad Nawaz; Iqbal, Jamshed; et al (July 2020, Journal of Biomolecular Structure and Dynamics)
3. Synthesis of agelastatin A and derivatives premised on a hidden symmetry element leading to analogs displaying anticancer activity

   https://doi.org/10.1016/j.tet.2021.132340  

   Xue, Haoran; Svatek, Haleigh; Bertonha, Ariane F.; Reisenauer, Keighley; Robinson, Joshua; Kim, Minwoo; Ingros, Alec; Ho, Matthew; Taube, Joseph; Romo, Daniel (August 2021, Tetrahedron)

   null (Ed.)
4. Synthesis and DNA binding profile of monomeric, dimeric, and trimeric derivatives of crystal violet

   https://doi.org/10.1016/j.bioorg.2018.10.040  

   Nuñez, Omar; Chavez, Bianca; Shaktah, Ryan; Garcia, Paola Pereda; Minehan, Thomas (March 2019, Bioorganic Chemistry)
5. Synthesis, Characterization, and HER Activity of Pendant Diamine Derivatives of NiATSM: Synthesis, Characterization, and HER Activity of Pendant Diamine Derivatives of NiATSM

   https://doi.org/10.1002/ejic.201900721  

   Calvary, Caleb A.; Hietsoi, Oleksandr; Strain, Jacob M.; Mashuta, Mark S.; Spurgeon, Joshua M.; Buchanan, Robert M.; Grapperhaus, Craig A. (August 2019, European Journal of Inorganic Chemistry)