More Like this

1. PartialFibers: An efficient method for predicting Drug-Drug Interactions

   Bumin, Aysegul; Huang, Kejun; Kahveci, Tamer (December 2023, Springer)

   Drug resistance is one of the fundamental challenges in modern medicine. Using combinations of drugs is an effective solution to counter drug resistance as is harder to develop resistance to multiple drugs simultaneously. Finding the correct dosage for each drug in the combination remains to be a challenging task. Testing all possible drug-drug combinations on various cell lines for different dosages in wet-lab experiments is infeasible since there are many combinations of drugs as well as their dosages yet the drugs and the cell lines are limited in availability and each wet-lab test is costly and time-consuming. Efficient and accurate in silico prediction methods are surely needed. Here we present a novel computational method, PartialFibers to address this challenge. Unlike existing prediction methods PartialFibers takes advantage of the distribution of the missing drug-drug interactions and effectively predicts the dosage of a drug in the combination. Our results on real datasets demonstrate that PartialFibers is more flexible, scalable, and achieves higher accuracy in less time than the state of the art algorithms. 

   more » « less
2. HyGNN: Drug-Drug Interaction Prediction via Hypergraph Neural Network

   https://doi.org/10.1109/ICDE55515.2023.00119  

   Saifuddin, Khaled Mohammed; Bumgardner, Briana; Tanvir, Farhan; Akbas, Esra (April 2023, 2023 IEEE 39th International Conference on Data Engineering (ICDE))
3. Detecting Drug-Drug Interactions using Protein Sequence-Structure Similarity Networks

   https://doi.org/10.1109/BIBM52615.2021.9669858  

   Islam, Saminur; Abbasi, Ahmed; Agarwal, Nitin; Zheng, Wanhong; Doretto, Gianfranco; Adjeroh, Donald A. (December 2021, 2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM))
4. Advancing Drug Delivery with Pocket Microneedle Achieving Dual-Drug Synchronization

   https://doi.org/10.1109/MEMS58180.2024.10439470  

   Ahmed, Rawda; Tan, Jun Ying; Li, Yuankai; Kim, Albert; Yoon, Donghoon; Shin, Crystal S; Kim, Jungkwun ‘JK’ (January 2024, IEEE)
5. Identifying articles relevant to drug-drug interaction: Addressing class imbalance

   https://doi.org/10.1109/BIBM.2017.8217818  

   Zhang, Gongbo; Bhattacharya, Moumita; Wu, Heng-Yi; Li, Pengyuan; Li, Lang; Shatkay, Hagit (November 2017, The IEEE International Conference on Bioinformatics and Biomedicine)