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   https://doi.org/10.4172/2314-7326.1000298  

   Emily Hone, Sajad Sarvari (July 2021, Journal of Neuroinfectious Diseases)

   null (Ed.)

   Stroke is an overwhelming neurological disease with very limited treatment options. As blood-brain barrier (BBB) integrity is well-implicated in the prevention of brain injury, its regulation may prove beneficial for stroke patients. BBB cerebro-vascular endothelial cells primarily utilize mitochondria as their energy-producing source, and mitochondrial function has revealed importance in outcomes for tissue post-stroke. In this review, bioenergetics in relation to BBB permeability in stroke is discussed. Moreover, what causes mitochondrial dysfunction following stroke is explored. 

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2. Materials for blood brain barrier modeling in vitro

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   Ferro, Magali P.; Heilshorn, Sarah C.; Owens, Roisin M. (April 2020, Materials Science and Engineering: R: Reports)
3. Blood-brain barrier crossing using magnetic stimulated nanoparticles

   https://doi.org/10.1016/j.jconrel.2022.03.007  

   Chen, Jingfan; Yuan, Muzhaozi; Madison, Caitlin A.; Eitan, Shoshana; Wang, Ya (May 2022, Journal of Controlled Release)
4. Ecdysone In The Blood-Brain Barrier And Male Courtship Behavior

   Waqar, M.; Dauwalder, B. (March 2023, Drosophila Research Conference)

   Abstract: We have previously found that the physiology of the blood-brain barrier (BBB) plays an important role in the regulation of male courtship behavior. Recently, we have shown that the nuclear hormone receptor Hr46 (Hormone receptor-like in 46) is required in the BBB of adult males for normal courtship in Drosophila melanogaster (Lama et al. 2022). Hr46 is well-characterized in development, where it is induced by the hormone Ecdysone and is a major mediator of the Ecdysone response. Using a reporter construct, we have found that Ecdysone is present in the BBB; however, nothing is known about its potential roles in these cells. Since, Hr46 is a major mediator of Ecdysone signaling; we hypothesize that Ecdysone is required in the BBB in the regulation of male courtship behavior. To test our hypothesis, we are using several different strategies to examine the role of Ecdysone and Ecdysone effectors in the BBB for courtship. These include the knockdown of the Ecdysone receptor (EcR) in mature males and lowering the levels of Ecdysone in the BBB by overexpressing an Ecdysone degrading enzyme. We are also testing the role of alternative Ecdysone effectors like DopEcR and an Ecdysone transporter in the BBB. 

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5. Modeling the blood–brain barrier: Beyond the endothelial cells

   https://doi.org/10.1016/j.cobme.2017.11.002  

   Gastfriend, Benjamin D.; Palecek, Sean P.; Shusta, Eric V. (March 2018, Current Opinion in Biomedical Engineering)