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Abstract Enantioenriched propargylic and allenic derivatives of silicon, germanium, and tin are versatile building blocks for stereoselective synthesis. Consequently, considerable efforts toward their efficient and selective synthesis have been made, both through classical approaches for chirality transfer and catalytic enantioselective strategies that employ the latest developments in transition metal catalysis, organocatalysis, and photoredox catalysis. In this review, we survey broadly applicable synthetic strategies and discuss the scope and mechanistic details for specific protocols that afford these compounds in a regio‐ and stereoselective manner.
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Recent Applications of Asymmetric Organocatalytic Methods in Total Synthesis
Natural products are the great sources of drugs and leading compounds in drug discovery, as it has been estimated that most of the current medicines are derived from natural products. Total synthesis of natural products, especially those of biological activities, has been an important part of organic chemistry, which, besides its potential practical utilities, also provides new inspirations and novel synthetic methodologies. Over the past two decades, organocatalysis has been shown to be very effective in controlling the stereochemistry of the reaction products and has found many applications in the asymmetric synthesis of natural products and related compounds. In this review, we will attempt to summarize some applications of asymmetric organocatalysis in the total synthesis of natural products and related compounds in the past seven years.
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- Award ID(s):
- 1664278
- PAR ID:
- 10215651
- Date Published:
- Journal Name:
- ChemistrySelect
- Volume:
- 6
- ISSN:
- 2365-6549
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
-
Accepted Manuscript
- Journal Article:
- https://doi.org/10.1002/slct.202004196
