Summary Quantile regression has become a widely used tool for analysing competing risk data. However, quantile regression for competing risk data with a continuous mark is still scarce. The mark variable is an extension of cause of failure in a classical competing risk model where cause of failure is replaced by a continuous mark only observed at uncensored failure times. An example of the continuous mark variable is the genetic distance that measures dissimilarity between the infecting virus and the virus contained in the vaccine construct. In this article, we propose a novel mark-specific quantile regression model. The proposed estimation method borrows strength from data in a neighbourhood of a mark and is based on an induced smoothed estimation equation, which is very different from the existing methods for competing risk data with discrete causes. The asymptotic properties of the resulting estimators are established across mark and quantile continuums. In addition, a mark-specific quantile-type vaccine efficacy is proposed and its statistical inference procedures are developed. Simulation studies are conducted to evaluate the finite sample performances of the proposed estimation and hypothesis testing procedures. An application to the first HIV vaccine efficacy trial is provided.
more »
« less
Specific Conformational Dynamics and Expansion Underpin a Multi-Step Mechanism for Specific Binding of p27 with Cdk2/Cyclin A
- Award ID(s):
- 1749778
- PAR ID:
- 10215736
- Date Published:
- Journal Name:
- Journal of Molecular Biology
- Volume:
- 432
- Issue:
- 9
- ISSN:
- 0022-2836
- Page Range / eLocation ID:
- 2998 to 3017
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
More Like this
-
-
With an ever-growing amount of collected data, the importance of visualization as an analysis component is growing in concert. The creation of good visualizations often doesn't happen in one step but is rather an iterative and exploratory process. However, this process is currently not well supported in most of the available visualization tools and systems. Visualization authors are forced to commit prematurely to particular design aspects of their creations, and when exploring potential variant visualizations, they are forced to adopt ad hoc techniques such as copying code snippets or keeping a collection of separate files. We propose variational visualizations as a model supporting open-ended exploration of the design space of information visualization. Together with that model, we present a prototype implementation in the form of a domain-specific language embedded in Purescript.more » « less
An official website of the United States government

