High-Sensitive Assay of Nucleic Acid Using Tetrahedral DNA Probes and DNA Concatamers with a Surface-Enhanced Raman Scattering/Surface Plasmon Resonance Dual-Mode Biosensor Based on a Silver Nanorod-Covered Silver Nanohole Array
- Award ID(s):
- 1808271
- PAR ID:
- 10219687
- Date Published:
- Journal Name:
- ACS Applied Materials & Interfaces
- Volume:
- 12
- Issue:
- 28
- ISSN:
- 1944-8244
- Page Range / eLocation ID:
- 31242 to 31254
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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Abstract Structural DNA nanotechnology enables the self‐organization of matter at the nanometer scale, but approaches to expand the inorganic and electrical functionality of these scaffolds remain limited. Developments in nucleic acid metallics have enabled the incorporation of site‐specific metal ions in DNA duplexes and provide a means of functionalizing the double helix with atomistic precision. Here a class of 2D DNA nanostructures that incorporate the cytosine‐Ag+‐cytosine (dC:Ag+:dC) base pair as a chemical trigger for self‐assembly is described. It is demonstrated that Ag+‐functionalized DNA can undergo programmable assembly into large arrays and rings, and can be further coassembled with guanine tetraplexes (G4). It is shown that 2D DNA lattices can be assembled with a variety of embedded nanowires at tunable spacing. These results serve as a foundation for further development of self‐assembled, metalated DNA nanostructures, with potential for high‐precision DNA nanoelectronics with nanometer pitch.more » « less
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