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1. Silver(I)‐Mediated 2D DNA Nanostructures

   https://doi.org/10.1002/smll.202407604  

   Vecchioni, Simon; Lo, Rainbow; Huang, Qiuyan; Wang, Kun; Ohayon, Yoel_P; Sha, Ruojie; Rothschild, Lynn_J; Wind, Shalom_J (November 2024, Small)

   Abstract Structural DNA nanotechnology enables the self‐organization of matter at the nanometer scale, but approaches to expand the inorganic and electrical functionality of these scaffolds remain limited. Developments in nucleic acid metallics have enabled the incorporation of site‐specific metal ions in DNA duplexes and provide a means of functionalizing the double helix with atomistic precision. Here a class of 2D DNA nanostructures that incorporate the cytosine‐Ag⁺‐cytosine (dC:Ag⁺:dC) base pair as a chemical trigger for self‐assembly is described. It is demonstrated that Ag⁺‐functionalized DNA can undergo programmable assembly into large arrays and rings, and can be further coassembled with guanine tetraplexes (G4). It is shown that 2D DNA lattices can be assembled with a variety of embedded nanowires at tunable spacing. These results serve as a foundation for further development of self‐assembled, metalated DNA nanostructures, with potential for high‐precision DNA nanoelectronics with nanometer pitch. 

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2. Chloride Ligands on DNA-Stabilized Silver Nanoclusters

   https://doi.org/10.1021/jacs.3c01366  

   Gonzàlez-Rosell, Anna; Malola, Sami; Guha, Rweetuparna; Arevalos, Nery R.; Matus, María Francisca; Goulet, Meghen E.; Haapaniemi, Esa; Katz, Benjamin B.; Vosch, Tom; Kondo, Jiro; et al (May 2023, Journal of the American Chemical Society)
3. Interrupted DNA and Slow Silver Cluster Luminescence

   https://doi.org/10.1021/acs.jpcc.3c01050  

   Lewis, David; Setzler, Caleb; Goodwin, Peter M.; Thomas, Kirsten; Branham, Makayla; Arrington, Caleb A.; Petty, Jeffrey T. (May 2023, The Journal of Physical Chemistry C)
4. Click catalysis and DNA conjugation using a nanoscale DNA/silver cluster pair

   https://doi.org/10.1039/D4NR02938K  

   Setzler, Caleb J; Petty, Jeffrey T (October 2024, Nanoscale)

   Silver cluster–DNA conjugates catalyze alkyne–azide cycloadditions. The catalytic activity of the cluster is regulated by the DNA host. 

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5. Structure and luminescence of DNA-templated silver clusters

   https://doi.org/10.1039/D0NA01005G  

   Gonzàlez-Rosell, Anna; Cerretani, Cecilia; Mastracco, Peter; Vosch, Tom; Copp, Stacy M. (March 2021, Nanoscale Advances)

   null (Ed.)

   DNA serves as a versatile template for few-atom silver clusters and their organized self-assembly. These clusters possess unique structural and photophysical properties that are programmed into the DNA template sequence, resulting in a rich palette of fluorophores which hold promise as chemical and biomolecular sensors, biolabels, and nanophotonic elements. Here, we review recent advances in the fundamental understanding of DNA-templated silver clusters (Ag N -DNAs), including the role played by the silver-mediated DNA complexes which are synthetic precursors to Ag N -DNAs, structure–property relations of Ag N -DNAs, and the excited state dynamics leading to fluorescence in these clusters. We also summarize the current understanding of how DNA sequence selects the properties of Ag N -DNAs and how sequence can be harnessed for informed design and for ordered multi-cluster assembly. To catalyze future research, we end with a discussion of several opportunities and challenges, both fundamental and applied, for the Ag N -DNA research community. A comprehensive fundamental understanding of this class of metal cluster fluorophores can provide the basis for rational design and for advancement of their applications in fluorescence-based sensing, biosciences, nanophotonics, and catalysis. 

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