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Transition-metal-catalyzed decarbonylation reactions of aliphatic carboxylic acids produce olefins via one carbon degradation. Recently, tremendous progress has been made in the development of new protocols for the synthesis of linear olefins by the formal acyl C–O activation mechanism of ubiquitous carboxylic acids. Various transition metals including nickel, palladium, iridium and iron have been shown to catalyze the reaction and achieve excellent yields and selectivity. The use of new ligand systems has resulted in unprecedented control of selectivity of elementary steps in the catalytic cycle. The development of new acyl precursors expands the access to α-olefins and offers promising perspectives for applications in preparative organic synthesis. In this article, we highlight the recent noteworthy developments in the transition-metal-catalyzed decarbonylation of carboxylic acids and discuss future challenges in this field.
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Boronic Acid Reagents for Transition‐Metal‐Mediated Cross‐Coupling with Proteins and Peptides
Abstract Transition‐metal catalysis provides new approaches to selectivity and the activation of otherwise inert functional groups. Bioconjugation with protein and peptide substrates presents numerous challenges of functional group activation and selectivity, and transitional‐metal approaches provide important alternative solutions to these challenges. This article describes the development of boronic acid reagents for new selective approaches to modification of peptides and proteins, focusing primarily on catalytic C−X bond formation.
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- Award ID(s):
- 1904865
- PAR ID:
- 10220852
- Publisher / Repository:
- Wiley Blackwell (John Wiley & Sons)
- Date Published:
- Journal Name:
- Israel Journal of Chemistry
- Volume:
- 61
- Issue:
- 7-8
- ISSN:
- 0021-2148
- Page Range / eLocation ID:
- p. 387-393
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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