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Abstract Sustainability in chemical synthesis is a major aspect of the current synthetic endeavors and, therefore, mimicking the biological process in the laboratory nowadays has the highest priority. Towards achieving this goal, designing organic reactions in domino mode rather than the multistep synthetic pathways and using organocatalysis instead of metal catalysis have received a lot of attention due to the inherent advantages of these processes in terms of synthetic efficiency and sustainability. As a result, the field of asymmetric organocatalytic domino reactions has witnessed tremendous progress in recent years. This review attempts to summarize the latest developments in asymmetric organocatalyzed domino reactions since 2012, with the emphasis on the catalysts and reaction modes. Discussions on the reaction mechanisms and the applications of the developed domino reaction methods in the synthesis of biologically active molecules and natural products are also included when appropriate. magnified image
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Recent Applications of Asymmetric Organocatalytic Methods in Total Synthesis
Abstract Natural products are the great sources of drugs and leading compounds in drug discovery, as it has been estimated that most of the current medicines are derived from natural products. Total synthesis of natural products, especially those of biological activities, has been an important part of organic chemistry, which, besides its potential practical utilities, also provides new inspirations and novel synthetic methodologies. Over the past two decades, organocatalysis has been shown to be very effective in controlling the stereochemistry of the reaction products and has found many applications in the asymmetric synthesis of natural products and related compounds. In this review we will attempt to summarize some applications of asymmetric organocatalysis in the total synthesis of natural products and related compounds in the past seven years.
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- Award ID(s):
- 1664278
- PAR ID:
- 10224338
- Publisher / Repository:
- Wiley Blackwell (John Wiley & Sons)
- Date Published:
- Journal Name:
- ChemistrySelect
- Volume:
- 6
- Issue:
- 9
- ISSN:
- 2365-6549
- Format(s):
- Medium: X Size: p. 2252-2280
- Size(s):
- p. 2252-2280
- Sponsoring Org:
- National Science Foundation
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