skip to main content
US FlagAn official website of the United States government
dot gov icon
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
https lock icon
Secure .gov websites use HTTPS
A lock ( lock ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Explore Research Products in the PAR
It may take a few hours for recently added research products to appear in PAR search results.


Title: On the influence of pore connectivity on performance of membrane filters
We study the influence of a membrane filter's internal pore structure on its flow and adsorptive fouling behaviour. Membrane performance is measured via (1) comparison between volumetric flow rate and throughput during filtration and (2) control of concentration of foulants at membrane pore outlets. Taking both measures into account, we address the merits and drawbacks of selected membrane pore structures. We first model layered planar membrane structures with intra-layer pore connections, and present comparisons between non-connected and connected structures. Our model predicts that membrane filters with connected pore structures lead to higher total volumetric throughput than those with non-connected structures, over the filter lifetime. We also provide a sufficient criterion for the concentration of particles escaping the filter to achieve a maximum in time (indicative of a membrane filter whose particle retention capability can deteriorate). Additionally, we find that the influence of intra-layer heterogeneity in pore-size distribution on filter performance depends on the connectivity properties of the pores.  more » « less
Award ID(s):
1646339
PAR ID:
10225594
Author(s) / Creator(s):
; ; ; ;
Date Published:
Journal Name:
Journal of Fluid Mechanics
Volume:
902
ISSN:
0022-1120
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
More Like this
  1. ; ; ; ; (, Biotechnology Progress)
    Abstract Tangential flow filtration is advantageous for bioreactor clarification as the permeate stream could be introduced directly to the subsequent product capture step. However, membrane fouling coupled with high product rejection has limited its use. Here, the performance of a reverse asymmetric hollow fiber membrane where the more open pore structure faces the feed stream and the barrier layer faces the permeate stream has been investigated. The open surface contains pores up to 40 μm in diameter while the tighter barrier layer has an average pore size of 0.4 μm. Filtration of Chinese hamster ovary cell feed streams has been investigated under conditions that could be expected in fed batch operations. The performance of the reverse asymmetric membrane is compared to that of symmetric hollow fiber membranes with nominal pore sizes of 0.2 and 0.65 μm. Laser scanning confocal microscopy was used to observe the locations of particle entrapment. The throughput of the reverse asymmetric membrane is significantly greater than the symmetric membranes. The membrane stabilizes an internal high permeability cake that acts like a depth filter. This stabilized cake can remove particulate matter that would foul the barrier layer if it faced the feed stream. An empirical model has been developed to describe the variation of flux and transmembrane pressure drop during filtration using reverse asymmetric membranes. Our results suggest that using a reverse asymmetric membrane could avoid severe flux decline associated with fouling of the barrier layer during bioreactor clarification. 
    more » « less
  2. ; (, Physics of Fluids)
    A pleated membrane filter consists of a porous membrane layer, which is surrounded by two supporting layers, and the whole structure is pleated and placed into a cylindrical cartridge. Pleated membrane filters are used in a variety of industrial applications, since they offer more surface area to volume ratio that is not found in equivalent flat filters. In this work, we introduce a novel three-dimensional model of a pleated membrane filter that consists of an empty region, a pleated region, and a hollow region. The advection diffusion equation is used to model contaminant concentration in the membrane pores along with Darcy's law to model the flow within the membrane and support layers, while the Stokes equation is used for the flow in the empty region and the hollow region. We further use the key assumptions of our model based on small aspect ratios of the filter cartridge and the pleated membrane to simplify the governing equations, which can be easily solved by numerical methods. By performing these steps, we seek to discover an optimal pleat packing density to find the optimum filter performance, while not exceeding a threshold for the particle concentration at the filter outlet. 
    more » « less
  3. ; ; ; ; (, Proceedings of the Royal Society B: Biological Sciences)
    Mobulid rays (manta and devil rays) use a highly specialized filtering apparatus to separate plankton food particles from seawater. Recent studies have indicated that captive vortices form within the microscale pores of the filter, which enhance filtration efficiency through a novel mechanism referred to as ricochet separation. The high throughput and clog resistance of this filtration process have led to the development of several bioinspired engineered filtration systems. However, it is still unclear how changes to the filter morphology influence the surrounding flow patterns and filtration efficiency. We address this question by examining the flow fields around and filtering properties of mobulid filters with systematically varied morphologies, using a combination of computational fluid dynamics and experiments on physical models. While the pore size is the principal determinant of filtration efficiency in a sieve filter, we found that the captive vortices in a mobulid filter grow or shrink to fill the pore, and changes in the pore size have modest effects. By contrast, the filtration efficiency appears to be highly sensitive to the orientation of the filter lobes (microscale plate-like structures). These results provide a foundation for interpreting the morphological differences between species and also for generating optimized bioinspired designs. 
    more » « less
  4. ; ; ; ; (, Biotechnology Progress)
    Abstract Tangential flow filtration (TFF) has many advantages for bioreactor harvesting, as the permeate could be introduced directly to the subsequent capture step. However, membrane fouling has limited its widespread use. This is particularly problematic given the high cell densities encountered today. Here, a reverse asymmetric membrane, where the more open surface faces the feed stream and the tighter barrier layer faces the permeate stream, has been investigated. The open surface contains pores up to 40 μm in diameter while the tighter barrier layer has an average pore size of 0.4 μm. Filtration of yeast suspensions has been conducted under a range of conditions. The yeast cells are trapped in the open pore structure. The membrane stabilizes an internal porous cake that acts like a depth filter. This stabilized cake layer can remove particulate matter that would foul the barrier layer if it faced the feed stream. As filtration continues, a surface cake layer forms on the membrane surface. A resistance in series model has been developed to describe the permeate flux during TFF. The model contains three fitted parameters which can easily be determined from constant pressure normal flow filtration experiments and total recycle constant flux TFF experiments. The model can be used to estimate the capacity of the filter for a given feed stream. Our results suggest that using a reverse asymmetric membrane could avoid severe flux decline associated with fouling of the barrier layer during bioreactor harvesting. 
    more » « less
  5. ; ; (, Fluids)
    null (Ed.)
    Membrane filtration fouling is a very complex process and is determined by many properties such as the membrane internal morphology, membrane pore structure, flow rate and contaminant properties. In a very slow filtration process or during the late stage of filtration, when the flow rate is naturally low and Péclet number is small, particle diffusion is essential and cannot be neglected, while in typical filtration models, especially in moderate and fast filtration process, the main contribution stems from the particle advection. The objectives of this study is to formulate mathematical models that can (i) investigate how filtration process varies under possible effects of particles diffusion; and (ii) describe how membrane morphology evolves and investigate the filtration performance during the filtration process. We also compare the results with the case that diffusion is less important and make a prediction about what kind of membrane filter pore structure should be employed to achieve a particular optimum filtration performance. According to our results, the filtrate and efficiency of particle separation are found to be under the trade-off relationship, and the selection of the membrane properties depends on the requirement of the filtration. 
    more » « less
  • Citation Formats
  • MLA
  • APA
  • Chicago
  • BibTeX
  • Save / Share this Record
  • Send to Email