More Like this

1. High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads

   https://doi.org/10.1093/nar/gky902  

   Liu, Hehua; Wang, Rui; Yu, Xiang; Shen, Fusheng; Lan, Wenxian; Haruehanroengra, Phensinee; Yao, Qingqing; Zhang, Jing; Chen, Yiqing; Li, Suhua; et al (October 2018, Nucleic Acids Research)
2. Calcium-Dependent Chemiluminescence Catalyzed by a Truncated c-MYC Promoter G-Triplex DNA

   https://doi.org/10.3390/molecules29184457  

   Das, Malay Kumar; Williams, Elizabeth P; Myhre, Mitchell W; David, Wendi M; Kerwin, Sean M (September 2024, Molecules)

   The dynamic landscape of non-canonical DNA G-quadruplex (G4) folding into G-triplex intermediates has led to the study of G-triplex structures and their ability to serve as peroxidase-mimetic DNAzymes. Here we report the formation, stability, and catalytic activity of a 5′-truncated c-MYC promoter region G-triplex, c-MYC-G3. Through circular dichroism, we demonstrated that c-MYC-G3 adopts a stable, parallel-stranded G-triplex conformation. The chemiluminescent oxidation of luminol by the peroxidase mimicking DNAzyme activity of c-MYC-G3 was increased in the presence of Ca2+ ions. We utilized surface plasmon resonance to characterize both c-MYC-G3 G-triplex formation and its interaction with hemin. The detailed study of c-MYC-G3 and its ability to form a G-triplex structure and its DNAzyme activity identifies issues that can be addressed in future G-triplex DNAzyme designs. 

   more » « less
3. Comparative Study of the Bending Free Energies of C- and G-Based DNA: A-, B-, and Z-DNA and Associated Mismatched Trinucleotide Repeats

   https://doi.org/10.1021/acs.jcim.5c00541  

   Fakharzadeh, Ashkan; Moradi, Mahmoud; Sagui, Celeste; Roland, Christopher (June 2025, Journal of Chemical Information and Modeling)
4. Interactions between heme and G-quadruplex DNA involve the oxygen of guanine

   https://doi.org/10.1016/j.jinorgbio.2025.112843  

   Chiura, Tapiwa; Pham, Minh N; Baum, Dana A; Mak, Piotr J (May 2025, Journal of Inorganic Biochemistry)
5. Comparative analysis reveals the expansion of mitochondrial DNA control region containing unusually high G-C tandem repeat arrays in Nasonia vitripennis

   https://doi.org/10.1016/j.ijbiomac.2020.11.007  

   Lin, Zi Jie; Wang, Xiaozhu; Wang, Jinbin; Tan, Yongjun; Tang, Xueming; Werren, John H.; Zhang, Dapeng; Wang, Xu (January 2021, International Journal of Biological Macromolecules)

   null (Ed.)