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This study expands and combines concepts from two of our earlier studies. One study reported the complementary halogen bonding and π-π charge transfer complexation observed between isomeric electron rich 4-N,N-dimethylaminophenylethynylpyridines and the electron poor halogen bond donor, 1-(3,5-dinitrophenylethynyl)-2,3,5,6-tetrafluoro-4-iodobenzene while the second study elaborated the ditopic halogen bonding of activated pyrimidines. Leveraging our understanding on the combination of these non-covalent interactions, we describe cocrystallization featuring ditopic halogen bonding and π-stacking. Specifically, red cocrystals are formed between the ditopic electron poor halogen bond donor 1-(3,5-dinitrophenylethynyl)-2,4,6-triflouro-3,5-diiodobenzene and each of electron rich pyrimidines 2- and 5-(4-N,N-dimethyl-aminophenylethynyl)pyrimidine. The X-ray single crystal structures of these cocrystals are described in terms of halogen bonding and electron donor-acceptor π-complexation. Computations confirm that the donor-acceptor π-stacking interactions are consistently stronger than the halogen bonding interactions and that there is cooperativity between π-stacking and halogen bonding in the crystals.
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Arylethynyl Helices Supported by π‐Stacking and Halogen Bonding
Abstract Co‐crystallization of a pyridyl‐containing arylethynyl (AE) moiety with 1,4‐diiodotetrafluorobenzene leads to unique, figure‐eight shaped helical motifs within the crystal lattice. A slight twist in the AE backbone allows each AE unit to simultaneously interact with haloarene units that are stacked on top of one another. Left‐handed (M) and right‐handed (P) helices are interspersed in a regular pattern throughout the crystal. The major driving forces for assembly are 1) halogen bonding between the pyridyl nitrogen atoms and the iodine substituents of the haloarene, with N⋅⋅⋅I distances between 2.81 and 2.84 Å, and 2) π‐π stacking of the haloarenes, with distances of approximately 3.57 Å between centroids. Halogen bonding and π‐π stacking not only work in concert, but also seem to mutually enhance one another. Calculations suggest that the presence of π‐π stacking modestly intensifies the halogen bonding interaction by <0.2 kcal/mol; likewise, halogen bonding to the haloarene enhances the π‐π stacking interaction by 0.59 kcal/mol.
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- PAR ID:
- 10237901
- Publisher / Repository:
- Wiley Blackwell (John Wiley & Sons)
- Date Published:
- Journal Name:
- ChemPlusChem
- Volume:
- 86
- Issue:
- 5
- ISSN:
- 2192-6506
- Format(s):
- Medium: X Size: p. 745-749
- Size(s):
- p. 745-749
- Sponsoring Org:
- National Science Foundation
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