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1. A neuromuscular model of human locomotion combines spinal reflex circuits with voluntary movements

   https://doi.org/10.1038/s41598-022-11102-1  

   Ramadan, Rachid ; Geyer, Hartmut ; Jeka, John ; Schöner, Gregor ; Reimann, Hendrik ( May 2022 , Scientific Reports)

   Existing models of human walking use low-level reflexes or neural oscillators to generate movement. While appropriate to generate the stable, rhythmic movement patterns of steady-state walking, these models lack the ability to change their movement patterns or spontaneously generate new movements in the specific, goal-directed way characteristic of voluntary movements. Here we present a neuromuscular model of human locomotion that bridges this gap and combines the ability to execute goal directed movements with the generation of stable, rhythmic movement patterns that are required for robust locomotion. The model represents goals for voluntary movements of the swing leg on the task level of swing leg joint kinematics. Smooth movements plans towards the goal configuration are generated on the task level and transformed into descending motor commands that execute the planned movements, using internal models. The movement goals and plans are updated in real time based on sensory feedback and task constraints. On the spinal level, the descending commands during the swing phase are integrated with a generic stretch reflex for each muscle. Stance leg control solely relies on dedicated spinal reflex pathways. Spinal reflexes stimulate Hill-type muscles that actuate a biomechanical model with eight internal joints and six free-body degrees of freedom. The model is able to generate voluntary, goal-directed reaching movements with the swing leg and combine multiple movements in a rhythmic sequence. During walking, the swing leg is moved in a goal-directed manner to a target that is updated in real-time based on sensory feedback to maintain upright balance, while the stance leg is stabilized by low-level reflexes and a behavioral organization switching between swing and stance control for each leg. With this combination of reflex-based stance leg and voluntary, goal-directed control of the swing leg, the model controller generates rhythmic, stable walking patterns in which the swing leg movement can be flexibly updated in real-time to step over or around obstacles.

    

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2. An Energy Shaping Exoskeleton Controller for Human Strength Amplification

   Thomas, Gray C. ; Gregg, Robert D. ( January 2021 , Proceedings of the IEEE Conference on Decision Control)

   null (Ed.)

   In this work, we introduce a novel approach to assistive exoskeleton (or powered orthosis) control which avoids needing task and gait phase information. Our approach is based on directly designing the Hamiltonian dynamics of the target closed-loop behavior, shaping the energy of the human and the robot. Relative to previous energy shaping controllers for assistive exoskeletons, we introduce ground reaction force and torque information into the target behavior definition, reformulate the kinematics so as to avoid explicit matching conditions due to under-actuation, and avoid the need to switch between swing and stance energy shapes. Our controller introduces new states into the target Hamiltonian energy that represent a virtual second leg that is connected to the physical leg using virtual springs. The impulse the human imparts to the physical leg is amplified and applied to the virtual leg, but the ground reaction force acts only on the physical leg. A state transformation allows the proposed control to be available using only encoders, an IMU, and ground reaction force sensors. We prove that this controller is stable and passive when acted on by the ground reaction force and demonstrate the controller's strength amplifying behavior in a simulation. A linear analysis based on small signal assumptions allows us to explain the relationship between our tuning parameters and the frequency domain amplification bandwidth. 

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3. Kinematic Trajectories in Response to Speed Perturbations in Walking Suggest Modular Task-Level Control of Leg Angle and Length

   https://doi.org/10.1093/icb/icac057  

   Schwaner, M. J. ; Nishikawa, K. C. ; Daley, M. A. ( May 2022 , Integrative And Comparative Biology)

   Navigating complex terrains requires dynamic interactions between the substrate, musculoskeletal, and sensorimotor systems. Current perturbation studies have mostly used visible terrain height perturbations, which do not allow us to distinguish among the neuromechanical contributions of feedforward control, feedback-mediated, and mechanical perturbation responses. Here, we use treadmill-belt speed perturbations to induce a targeted perturbation to foot speed only, and without terrain-induced changes in joint posture and leg loading at stance onset. Based on previous studies suggesting a proximo-distal gradient in neuromechanical control, we hypothesized that distal joints would exhibit larger changes in joint kinematics, compared to proximal joints. Additionally, we expected birds to use feedforward strategies to increase the intrinsic stability of gait. To test these hypotheses, seven adult guinea fowl were video recorded while walking on a motorized treadmill, during both steady and perturbed trials. Perturbations consisted of repeated exposures to a deceleration and acceleration of the treadmill-belt speed. Surprisingly, we found that joint angular trajectories and center of mass fluctuations remain very similar, despite substantial perturbation of foot velocity by the treadmill belt. Hip joint angular trajectories exhibit the largest changes, with the birds adopting a slightly more flexed position across all perturbed strides. Additionally, we observed increased stride duration across all strides, consistent with feedforward changes in the control strategy. The speed perturbations mainly influenced the timing of stance and swing, with the largest kinematic changes in the strides directly following a deceleration. Our findings do not support the general hypothesis of a proximo-distal gradient in joint control, as distal joint kinematics remain largely unchanged. Instead, we find that leg angular trajectory and the timing of stance and swing are most sensitive to this specific perturbation, and leg length actuation remains largely unchanged. Our results are consistent with modular task-level control of leg length and leg angle actuation, with different neuromechanical control and perturbation sensitivity in each actuation mode. Distal joints appear to be sensitive to changes in vertical loading but not foot fore-aft velocity. Future directions should include in vivo studies of muscle activation and force–length dynamics to provide more direct evidence of the sensorimotor control strategies for stability in response to belt-speed perturbations.

    

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4. Biologically Inspired Optimal Terminal Iterative Learning Control for the Swing Phase of Gait in a Hybrid Neuroprosthesis: A Modeling Study

   https://doi.org/10.3390/bioengineering9020071  

   Makowski, Nathaniel S. ; Fitzpatrick, Marshaun N. ; Triolo, Ronald J. ; Reyes, Ryan-David ; Quinn, Roger D. ; Audu, Musa ( February 2022 , Bioengineering)

   (1) Background: An iterative learning control (ILC) strategy was developed for a “Muscle First” Motor-Assisted Hybrid Neuroprosthesis (MAHNP). The MAHNP combines a backdrivable exoskeletal brace with neural stimulation technology to enable persons with paraplegia due to spinal cord injury (SCI) to execute ambulatory motions and walk upright. (2) Methods: The ILC strategy was developed to swing the legs in a biologically inspired ballistic fashion. It maximizes muscular recruitment and activates the motorized exoskeletal bracing to assist the motion as needed. The control algorithm was tested using an anatomically realistic three-dimensional musculoskeletal model of the lower leg and pelvis suitably modified to account for exoskeletal inertia. The model was developed and tested with the OpenSim biomechanical modeling suite. (3) Results: Preliminary data demonstrate the efficacy of the controller in swing-leg simulations and its ability to learn to balance muscular and motor contributions to improve performance and accomplish consistent stepping. In particular, the controller took 15 iterations to achieve the desired outcome with 0.3% error. 

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5. Nonholonomic Virtual Constraints for Control of Powered Prostheses Across Walking Speeds

   https://doi.org/10.1109/TCST.2021.3133823  

   Horn, Jonathan ; Gregg, Robert D. ( December 2021 , IEEE transactions on control systems technology)

   This paper presents a method to design a nonholonomic virtual constraint (NHVC) controller that produces multiple distinct stance-phase trajectories for corresponding walking speeds. NHVCs encode velocity-dependent joint trajectories via momenta conjugate to the unactuated degree(s)-of-freedom of the system. We recently introduced a method for designing NHVCs that allow for stable bipedal robotic walking across variable terrain slopes. This work extends the notion of NHVCs for application to variable-cadence powered prostheses. Using the segmental conjugate momentum for the prosthesis, an optimization problem is used to design a single stance-phase NHVC for three distinct walking speed trajectories (slow, normal, and fast). This stance-phase controller is implemented with a holonomic swing phase controller on a powered knee-ankle prosthesis, and experiments are conducted with an able-bodied user walking in steady and non-steady velocity conditions. The control scheme is capable of representing 1) multiple, task-dependent reference trajectories, and 2) walking gait variance due to both temporal and kinematic changes in user motion. 

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