The direct C−H acyloxylation of polycyclic aromatic hydrocarbons (PAHs) with carboxylic acids as the acyloxylating agents was achieved via the electron‐donor‐acceptor (EDA) complexes between PAHs and
Rh(I)‐Catalyzed Direct C6−H Arylation of 2‐Pyridones with Aryl Carboxylic Acids
A Rh(I)‐catalyzed C6‐selective C−H arylation of 2‐pyridones with inexpensive, readily available, safe and structurally diverse aryl carboxylic acids with the aid of a pyridine directing group is developed. This decarbonylative arylation protocol features an easy‐to‐handle catalytic system, and is amenable to diversely substituted 2‐pyridones and aryl carboxylic acids. It allows access to a wide range of C6‐arylated 2‐pyridones, including those that are difficult to prepare using conventional C−H arylation processes. The method tolerates various electron‐neutral, electron‐rich and electron‐deficient functional groups, and affords the products in 41–91% yields.
- Award ID(s):
- 1902509
- NSF-PAR ID:
- 10253971
- Publisher / Repository:
- Wiley Blackwell (John Wiley & Sons)
- Date Published:
- Journal Name:
- Advanced Synthesis & Catalysis
- Volume:
- 363
- Issue:
- 16
- ISSN:
- 1615-4150
- Page Range / eLocation ID:
- p. 3995-4001
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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