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Neurological disorders generally involve multiple kinds of changes in the functional and structural properties of the brain. In this study, we develop a CNN-based multimodal deep learning pipeline by exploiting both functional and structural neuroimaging features to generate full-brain maps that encode significant differences between patient groups and between modalities in terms of their distinctive contribution towards diagnostic classification of Alzheimer’s disease. Through a repeated cross-validation procedure and robust statistical analysis, we show that our approach can be used to encode highly discriminative and abstract information from full-brain data, while also retaining the ability to identify and categorize significantly contributing voxel-level features based on their salient strength in various diagnostic and modality-related contexts. Our results on an Alzheimer’s disease classification task show that such approaches can be used for creating more elaborately defined biomarkers for brain disorders.
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Learning Multi-resolution Graph Edge Embedding for Discovering Brain Network Dysfunction in Neurological Disorders
Tremendous recent literature show that associations between different brain regions, i.e., brain connectivity, provide early symptoms of neurological disorders. Despite significant efforts made for graph neural network (GNN) techniques, their focus on graph nodes makes the state-of-the-art GNN methods not suitable for classifying brain connectivity as graphs where the objective is to characterize disease-relevant network dysfunction patterns on graph links. To address this issue, we propose Multi-resolution Edge Network (MENET) to detect disease-specific connectomic benchmarks with high discrimination power across diagnostic categories. The core of MENET is a novel graph edge-wise transform that we propose, which allows us to capture multi-resolution “connectomic” features. Using a rich set of the connectomic features, we devise a graph learning framework to jointly select discriminative edges and assign diagnostic labels for graphs. Experiments on two real datasets show that MENET accurately predicts diagnostic labels and identify brain connectivities highly associated with neurological disorders such as Alzheimer’s Disease and Attention-Deficit/Hyperactivity Disorder.
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- PAR ID:
- 10264973
- Date Published:
- Journal Name:
- Lecture notes in computer science
- Volume:
- 12729
- ISSN:
- 0302-9743
- Page Range / eLocation ID:
- 253-266
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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Accepted Manuscript1.0
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