Masked alcohols are particularly appealing as directing groups because of the ubiquity of hydroxy groups in organic small molecules. Herein, we disclose a general strategy for aliphatic γ‐C(sp3)−H functionalization guided by a masked alcohol. Specifically, we determine that sulfamate ester derived nitrogen‐centered radicals mediate 1,6‐hydrogen‐atom transfer (HAT) processes to guide γ‐C(sp3)−H chlorination. This reaction proceeds through a light‐initiated radical chain‐propagation process and is capable of installing chlorine atoms at primary, secondary, and tertiary centers.
- Award ID(s):
- 1836498
- NSF-PAR ID:
- 10277426
- Date Published:
- Journal Name:
- Physical Chemistry Chemical Physics
- Volume:
- 22
- Issue:
- 35
- ISSN:
- 1463-9076
- Page Range / eLocation ID:
- 19613 to 19622
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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