skip to main content
US FlagAn official website of the United States government
dot gov icon
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
https lock icon
Secure .gov websites use HTTPS
A lock ( lock ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Explore Research Products in the PAR
It may take a few hours for recently added research products to appear in PAR search results.


Title: Background-free dual-mode optical and 13C magnetic resonance imaging in diamond particles
Multimodal imaging—the ability to acquire images of an object through more than one imaging mode simultaneously—has opened additional perspectives in areas ranging from astronomy to medicine. In this paper, we report progress toward combining optical and magnetic resonance (MR) imaging in such a “dual” imaging mode. They are attractive in combination because they offer complementary advantages of resolution and speed, espe- cially in the context of imaging in scattering environments. Our approach relies on a specific material platform, microdiamond par- ticles hosting nitrogen vacancy (NV) defect centers that fluoresce brightly under optical excitation and simultaneously “hyperpolar- ize” lattice 13C nuclei, making them bright under MR imaging. We highlight advantages of dual-mode optical and MR imag- ing in allowing background-free particle imaging and describe regimes in which either mode can enhance the other. Leveraging the fact that the two imaging modes proceed in Fourier-reciprocal domains (real and k-space), we propose a sampling protocol that accelerates image reconstruction in sparse-imaging scenar- ios. Our work suggests interesting possibilities for the simulta- neous optical and low-field MR imaging of targeted diamond nanoparticles.  more » « less
Award ID(s):
1903803
PAR ID:
10281837
Author(s) / Creator(s):
Date Published:
Journal Name:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
118
Issue:
21
ISSN:
0027-8424
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
More Like this
  1. ; ; ; ; ; ; ; ; ; ; et al (, Proceedings of the National Academy of Sciences)
    null (Ed.)
    Multimodal imaging—the ability to acquire images of an object through more than one imaging mode simultaneously—has opened additional perspectives in areas ranging from astronomy to medicine. In this paper, we report progress toward combining optical and magnetic resonance (MR) imaging in such a “dual” imaging mode. They are attractive in combination because they offer complementary advantages of resolution and speed, especially in the context of imaging in scattering environments. Our approach relies on a specific material platform, microdiamond particles hosting nitrogen vacancy (NV) defect centers that fluoresce brightly under optical excitation and simultaneously “hyperpolarize” lattice C 13 nuclei, making them bright under MR imaging. We highlight advantages of dual-mode optical and MR imaging in allowing background-free particle imaging and describe regimes in which either mode can enhance the other. Leveraging the fact that the two imaging modes proceed in Fourier-reciprocal domains (real and k-space), we propose a sampling protocol that accelerates image reconstruction in sparse-imaging scenarios. Our work suggests interesting possibilities for the simultaneous optical and low-field MR imaging of targeted diamond nanoparticles. 
    more » « less
  2. ; ; ; (, Sensors)
    Common path DHM systems are the most robust DHM systems as they are based on self-interference and are thus less prone to external fluctuations. A common issue amongst these DHM systems is that the two replicas of the sample’s information overlay due to self-interference, making them only suitable for imaging sparse samples. This overlay has restricted the use of common-path DHM systems in material science. The overlay can be overcome by limiting the sample’s field of view to occupy only half of the imaging field of view or by using an optical spatial filter. In this work, we have implemented optical spatial filtering in a common-path DHM system using a Fresnel biprism. We have analyzed the optimal pinhole size by evaluating the frequency content of the reconstructed phase images of a star target. We have also measured the accuracy of the system and the sensitivity to noise for different pinhole sizes. Finally, we have proposed the first dual-mode common-path DHM system using a Fresnel biprism. The performance of the dual-model DHM system has been evaluated experimentally using transmissive and reflective microscopic samples. 
    more » « less
  3. ; ; ; ; ; ; (, ArXivorg)
    Mid-infrared (MIR) spectrometers are invaluable tools for molecular fingerprinting and hyper-spectral imaging. Among the available spectroscopic approaches, GHz MIR dual-comb absorption spectrometers have the potential to simultaneously combine the high-speed, high spectral resolution, and broad optical bandwidth needed to accurately study complex, transient events in chemistry, combustion, and microscopy. However, such a spectrometer has not yet been demonstrated due to the lack of GHz MIR frequency combs with broad and full spectral coverage. Here, we introduce the first broadband MIR frequency comb laser platform at 1 GHz repetition rate that achieves spectral coverage from 3 to 13 {\mu}m. This frequency comb is based on a commercially available 1.56 {\mu}m mode-locked laser, robust all-fiber Er amplifiers and intra-pulse difference frequency generation (IP-DFG) of few-cycle pulses in \c{hi}(2) nonlinear crystals. When used in a dual comb spectroscopy (DCS) configuration, this source will simultaneously enable measurements with {\mu}s time resolution, 1 GHz (0.03 cm-1) spectral point spacing and a full bandwidth of >5 THz (>166 cm-1) anywhere within the MIR atmospheric windows. This represents a unique spectroscopic resource for characterizing fast and non-repetitive events that are currently inaccessible with other sources. 
    more » « less
  4. ; ; ; ; ; ; (, Light: Science & Applications)
    Abstract Mid-infrared (MIR) spectrometers are invaluable tools for molecular fingerprinting and hyper-spectral imaging. Among the available spectroscopic approaches, GHz MIR dual-comb absorption spectrometers have the potential to simultaneously combine the high-speed, high spectral resolution, and broad optical bandwidth needed to accurately study complex, transient events in chemistry, combustion, and microscopy. However, such a spectrometer has not yet been demonstrated due to the lack of GHz MIR frequency combs with broad and full spectral coverage. Here, we introduce the first broadband MIR frequency comb laser platform at 1 GHz repetition rate that achieves spectral coverage from 3 to 13 µm. This frequency comb is based on a commercially available 1.56 µm mode-locked laser, robust all-fiber Er amplifiers and intra-pulse difference frequency generation (IP-DFG) of few-cycle pulses inχ(2)nonlinear crystals. When used in a dual comb spectroscopy (DCS) configuration, this source will simultaneously enable measurements with μs time resolution, 1 GHz (0.03 cm−1) spectral point spacing and a full bandwidth of >5 THz (>166 cm−1) anywhere within the MIR atmospheric windows. This represents a unique spectroscopic resource for characterizing fast and non-repetitive events that are currently inaccessible with other sources. 
    more » « less
  5. ; ; ; ; ; ; ; ; (, Virtual Reality)
    Recent innovations in virtual and mixed-reality (VR/MR) technologies have enabled innovative hands-on training applications in high-risk/high-value fields such as medicine, flight, and worker-safety. Here, we present a detailed description of a novel VR/MR tactile user interactions/interface (TUI) hardware and software development framework that enables the rapid and cost-effective no-code development, optimization, and distribution of fully authentic hands-on VR/MR laboratory training experiences in the physical and life sciences. We applied our framework to the development and optimization of an introductory pipette calibration activity that is often carried out in real chemistry and biochemistry labs. Our approach provides users with nuanced real-time feedback on both their psychomotor skills during data acquisition and their attention to detail when conducting data analysis procedures. The cost-effectiveness of our approach relative to traditional face-to-face science labs improves access to quality hands-on science lab experiences. Importantly, the no-code nature of this Hands-On Virtual-Reality (HOVR) Lab platform enables faculties to iteratively optimize VR/MR experiences to meet their student’s targeted needs without costly software development cycles. Our platform also accommodates TUIs using either standard virtual-reality controllers (VR TUI mode) or fully functional hand-held physical lab tools (MR TUI mode). In the latter case, physical lab tools are strategically retrofitted with optical tracking markers to enable tactile, experimental, and analytical authenticity scientific experimentation. Preliminary user study data highlights the strengths and weaknesses of our generalized approach regarding student affective and cognitive student learning outcomes. 
    more » « less
  • Citation Formats
  • MLA
  • APA
  • Chicago
  • BibTeX
  • Save / Share this Record
  • Send to Email