Although most dramatic structural changes occur in the perinatal period, a growing body of evidences demonstrates that adolescence and early adulthood are also important for substantial neurodevelopment. We were thus motivated to explore brain development during puberty by evaluating functional connectivity network (FCN) differences between childhood and young adulthood using multi‐paradigm task‐based functional magnetic resonance imaging (fMRI) measurements. Different from conventional multigraph based FCN construction methods where the graph network was built independently for each modality/paradigm, we proposed a multigraph learning model in this work. It promises a better fitting to FCN construction by jointly estimating brain network from multi‐paradigm fMRI time series, which may share common graph structures. To investigate the hub regions of the brain, we further conducted graph Fourier transform (GFT) to divide the fMRI BOLD time series of a node within the brain network into a range of frequencies. Then we identified the hub regions characterizing brain maturity through eigen‐analysis of the low frequency components, which were believed to represent the organized structures shared by a large population. The proposed method was evaluated using both synthetic and real data, which demonstrated its effectiveness in extracting informative brain connectivity patterns. We detected 14 hub regions from the child group and 12 hub regions from the young adult group. We show the significance of these findings with a discussion of their functions and activation patterns as a function of age. In summary, our proposed method can extract brain connectivity network more accurately by considering the latent common structures between different fMRI paradigms, which are significant for both understanding brain development and recognizing population groups of different ages.
- Award ID(s):
- 1830547
- NSF-PAR ID:
- 10282027
- Date Published:
- Journal Name:
- Network Science
- Volume:
- 9
- Issue:
- 1
- ISSN:
- 2050-1242
- Page Range / eLocation ID:
- 99 to 122
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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INTRODUCTION: Apollo-11 (A-11) was the first manned space mission to successfully bring astronauts to the moon and return them safely. Effective team based communications is required for mission specialists to work collaboratively to learn, engage, and solve complex problems. As part of NASA’s goal in assessing team and mission success, all vital speech communications between these personnel were recorded using the multi-track SoundScriber system onto analog tapes, preserving their contribution in the success of one of the greatest achievements in human history. More than +400 personnel served as mission specialists/support who communicated across 30 audio loops, resulting in +9k hours of data for A-11. To ensure success of this mission, it was necessary for teams to communicate, learn, and address problems in a timely manner. Previous research has found that compatibility of individual personalities within teams is important for effective team collaboration of those individuals. Hence, it is essential to identify each speaker’s role during an Apollo mission and analyze group communications for knowledge exchange and problem solving to achieve a common goal. Assessing and analyzing speaker roles during the mission can allow for exploring engagement analysis for multi-party speaker situations. METHOD: The UTDallas Fearless steps Apollo data is comprised of 19,000 hours (A-11,A-13,A-1) possessing unique and multiple challenges as it is characterized by severe noise and degradation as well as overlap instances over the 30 channels. For our study, we have selected a subset of 100 hours manually transcribed by professional annotators for speaker labels. The 100 hours are obtained from three mission critical events: 1. Lift-Off (25 hours) 2. Lunar-Landing (50 hours) 3. Lunar-Walking (25 hours). Five channels of interest, out of 30 channels were selected with the most speech activity, the primary speakers operating these five channels are command/owners of these channels. For our analysis, we select five speaker roles: Flight Director (FD), Capsule Communicator (CAPCOM), Guidance, Navigation and, Control (GNC), Electrical, environmental, and consumables manager (EECOM), and Network (NTWK). To track and tag individual speakers across our Fearless Steps audio dataset, we use the concept of ‘where’s Waldo’ to identify all instances of our speakers-of-interest across a cluster of other speakers. Also, to understand speaker roles of our speaker-of-interests, we use speaker duration of primary speaker vs secondary speaker and speaker turns as our metrics to determine the role of the speaker and to understand their responsibility during the three critical phases of the mission. This enables a content linking capability as well as provide a pathway to analyzing group engagement, group dynamics of people working together in an enclosed space, psychological effects, and cognitive analysis in such individuals. IMPACT: NASA’s Apollo Program stands as one of the most significant contributions to humankind. This collection opens new research options for recognizing team communication, group dynamics, and human engagement/psychology for future deep space missions. Analyzing team communications to achieve such goals would allow for the formulation of educational and training technologies for assessment of STEM knowledge, task learning, and educational feedback. Also, identifying these personnel can help pay tribute and yield personal recognition to the hundreds of notable engineers and scientist who made this feat possible. ILLUSTRATION: In this work, we propose to illustrate how a pre-trained speech/language network can be used to obtain powerful speaker embeddings needed for speaker diarization. This framework is used to build these learned embeddings to label unique speakers over sustained audio streams. To train and test our system, we will make use of Fearless Steps Apollo corpus, allowing us to effectively leverage a limited label information resource (100 hours of labeled data out of +9000 hours). Furthermore, we use the concept of 'Finding Waldo' to identify key speakers of interest (SOI) throughout the Apollo-11 mission audio across multiple channel audio streams.more » « less
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Abstract Patterns of whole-brain fMRI functional connectivity, or connectomes, are unique to individuals. Previous work has identified subsets of functional connections within these patterns whose strength predicts aspects of attention and cognition. However, overall features of these connectomes, such as how stable they are over time and how similar they are to a group-average (typical) or high-performance (optimal) connectivity pattern, may also reflect cognitive and attentional abilities. Here, we test whether individuals who express more stable, typical, optimal, and distinctive patterns of functional connectivity perform better on cognitive tasks using data from three independent samples. We find that individuals with more stable task-based functional connectivity patterns perform better on attention and working memory tasks, even when controlling for behavioral performance stability. Additionally, we find initial evidence that individuals with more typical and optimal patterns of functional connectivity also perform better on these tasks. These results demonstrate that functional connectome stability within individuals and similarity across individuals predicts individual differences in cognition.
- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1017/nws.2020.39
