We report a distinct difference in the interactions of the glycans of the host-cell receptor, ACE2, with SARS-CoV-2 and SARS-CoV S–protein receptor-binding domains (RBDs). Our analysis demonstrates that the ACE2 glycan at N322 enhances interactions with the SARS-CoV-2 RBD while the ACE2 glycan at N90 may offer protection against infections of both coronaviruses depending on its composition. The interactions of the ACE2 glycan at N322 with SARS-CoV RBD are blocked by the presence of the RBD glycan at N357 of the SARS-CoV RBD. The absence of this glycosylation site on SARS-CoV-2 RBD may enhance its binding with ACE2.
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Sewage, Salt, Silica, and SARS-CoV-2 (4S): An Economical Kit-Free Method for Direct Capture of SARS-CoV-2 RNA from Wastewater
- Award ID(s):
- 1633740
- PAR ID:
- 10285815
- Date Published:
- Journal Name:
- Environmental Science & Technology
- Volume:
- 55
- Issue:
- 8
- ISSN:
- 0013-936X
- Page Range / eLocation ID:
- 4880 to 4888
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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