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Title: Chronic Cranial Windows for Long Term Multimodal Neurovascular Imaging in Mice
Chronic cranial windows allow for longitudinal brain imaging experiments in awake, behaving mice. Different imaging technologies have their unique advantages and combining multiple imaging modalities offers measurements of a wide spectrum of neuronal, glial, vascular, and metabolic parameters needed for comprehensive investigation of physiological and pathophysiological mechanisms. Here, we detail a suite of surgical techniques for installation of different cranial windows targeted for specific imaging technologies and their combination. Following these techniques and practices will yield higher experimental success and reproducibility of results.  more » « less
Award ID(s):
1633516
PAR ID:
10288419
Author(s) / Creator(s):
; ; ; ; ; ; ; ;
Date Published:
Journal Name:
Frontiers in Physiology
Volume:
11
ISSN:
1664-042X
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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