Artificial metalloenzymes (ArMs) are commonly used to control the stereoselectivity of catalytic reactions, but controlling chemoselectivity remains challenging. In this study, we engineer a dirhodium ArM to catalyze diazo cross‐coupling to form an alkene that, in a one‐pot cascade reaction, is reduced to an alkane with high enantioselectivity (typically >99 %
Artificial metalloenzymes (ArMs) are commonly used to control the stereoselectivity of catalytic reactions, but controlling chemoselectivity remains challenging. In this study, we engineer a dirhodium ArM to catalyze diazo cross‐coupling to form an alkene that, in a one‐pot cascade reaction, is reduced to an alkane with high enantioselectivity (typically >99 %
- Award ID(s):
- 1700982
- NSF-PAR ID:
- 10288640
- Publisher / Repository:
- Wiley Blackwell (John Wiley & Sons)
- Date Published:
- Journal Name:
- Angewandte Chemie International Edition
- Volume:
- 60
- Issue:
- 44
- ISSN:
- 1433-7851
- Page Range / eLocation ID:
- p. 23672-23677
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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