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Title: Integrating Biomaterials and Genome Editing Approaches to Advance Biomedical Science
The recent discovery and subsequent development of the CRISPR–Cas9 (clustered regularly interspaced short palindromic repeat–CRISPR-associated protein 9) platform as a precise genome editing tool have transformed biomedicine. As these CRISPR-based tools have matured, multiple stages of the gene editing process and the bioengineering of human cells and tissues have advanced. Here, we highlight recent intersections in the development of biomaterials and genome editing technologies. These intersections include the delivery of macromolecules, where biomaterial platforms have been harnessed to enable nonviral delivery of genome engineering tools to cells and tissues in vivo. Further, engineering native-like biomaterial platforms for cell culture facilitates complex modeling of human development and disease when combined with genome engineering tools. Deeper integration of biomaterial platforms in these fields could play a significant role in enabling new breakthroughs in the application of gene editing for the treatment of human disease.  more » « less
Award ID(s):
1709527 1830957
NSF-PAR ID:
10293531
Author(s) / Creator(s):
; ; ;
Date Published:
Journal Name:
Annual Review of Biomedical Engineering
Volume:
23
Issue:
1
ISSN:
1523-9829
Page Range / eLocation ID:
493 to 516
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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