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1. A structured brain‐wide and genome‐wide association study using ADNI PET images

   https://doi.org/10.1002/cjs.11605  

   Li, Yanming; Nan, Bin; Zhu, Ji; for_the_Alzheimer's_Disease_Neuroimaging_Initiative (February 2021, Canadian Journal of Statistics)

   Abstract A multistage variable selection method is introduced for detecting association signals in structured brain‐wide and genome‐wide association studies (brain‐GWAS). Compared to conventional methods that link one voxel to one single nucleotide polymorphism (SNP), our approach is more efficient and powerful in selecting the important signals by integrating anatomic and gene grouping structures in the brain and the genome, respectively. It avoids resorting to a large number of multiple comparisons while effectively controlling the false discoveries. Validity of the proposed approach is demonstrated by both theoretical investigation and numerical simulations. We apply our proposed method to a brain‐GWAS using Alzheimer's Disease Neuroimaging Initiative positron emission tomography (ADNI PET) imaging and genomic data. We confirm previously reported association signals and also uncover several novel SNPs and genes that are either associated with brain glucose metabolism or have their association significantly modified by Alzheimer's disease status. 

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2. Thermal management and packaging of wide and ultra-wide bandgap power devices: a review and perspective

   https://doi.org/10.1088/1361-6463/acb4ff  

   Qin, Yuan; Albano, Benjamin; Spencer, Joseph; Lundh, James Spencer; Wang, Boyan; Buttay, Cyril; Tadjer, Marko; DiMarino, Christina; Zhang, Yuhao (February 2023, Journal of Physics D: Applied Physics)

   Abstract Power semiconductor devices are fundamental drivers for advances in power electronics, the technology for electric energy conversion. Power devices based on wide-bandgap (WBG) and ultra-wide bandgap (UWBG) semiconductors allow for a smaller chip size, lower loss and higher frequency compared with their silicon (Si) counterparts, thus enabling a higher system efficiency and smaller form factor. Amongst the challenges for the development and deployment of WBG and UWBG devices is the efficient dissipation of heat, an unavoidable by-product of the higher power density. To mitigate the performance limitations and reliability issues caused by self-heating, thermal management is required at both device and package levels. Packaging in particular is a crucial milestone for the development of any power device technology; WBG and UWBG devices have both reached this milestone recently. This paper provides a timely review of the thermal management of WBG and UWBG power devices with an emphasis on packaged devices. Additionally, emerging UWBG devices hold good promise for high-temperature applications due to their low intrinsic carrier density and increased dopant ionization at elevated temperatures. The fulfillment of this promise in system applications, in conjunction with overcoming the thermal limitations of some UWBG materials, requires new thermal management and packaging technologies. To this end, we provide perspectives on the relevant challenges, potential solutions and research opportunities, highlighting the pressing needs for device–package electrothermal co-design and high-temperature packages that can withstand the high electric fields expected in UWBG devices. 

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3. Wide binaries from the H3 survey: the thick disc and halo have similar wide binary fractions

   https://doi.org/10.1093/mnras/stac650  

   Hwang, Hsiang-Chih; Ting, Yuan-Sen; Conroy, Charlie; Zakamska, Nadia L.; El-Badry, Kareem; Cargile, Phillip; Zaritsky, Dennis; Chandra, Vedant; Han, Jiwon Jesse; Speagle, Joshua S.; et al (March 2022, Monthly Notices of the Royal Astronomical Society)

   ABSTRACT Due to the different environments in the Milky Way’s disc and halo, comparing wide binaries in the disc and halo is key to understanding wide binary formation and evolution. By using Gaia Early Data Release 3, we search for resolved wide binary companions in the H3 survey, a spectroscopic survey that has compiled ∼150 000 spectra for thick-disc and halo stars to date. We identify 800 high-confidence (a contamination rate of 4 per cent) wide binaries and two resolved triples, with binary separations mostly between 103 and 105 au and a lowest [Fe/H] of −2.7. Based on their Galactic kinematics, 33 of them are halo wide binaries, and most of those are associated with the accreted Gaia-Sausage-Enceladus galaxy. The wide binary fraction in the thick disc decreases toward the low metallicity end, consistent with the previous findings for the thin disc. Our key finding is that the halo wide binary fraction is consistent with the thick-disc stars at a fixed [Fe/H]. There is no significant dependence of the wide binary fraction on the α-captured abundance. Therefore, the wide binary fraction is mainly determined by the iron abundance, not their disc or halo origin nor the α-captured abundance. Our results suggest that the formation environments play a major role for the wide binary fraction, instead of other processes like radial migration that only apply to disc stars. 

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4. AWStream: adaptive wide-area streaming analytics

   https://doi.org/10.1145/3230543.3230554  

   Zhang, Ben; Jin, Xin; Ratnasamy, Sylvia; Wawrzynek, John; Lee, Edward A. (January 2018, ACM SIGCOMM)
5. Brain-wide interactions between neural circuits

   https://doi.org/10.1016/j.conb.2020.12.012  

   Abbott, Larry; Svoboda, Karel (December 2020, Current Opinion in Neurobiology)

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