FEAST of biosensors: Food, environmental and agricultural sensing technologies (FEAST) in North America
- NSF-PAR ID:
- 10301149
- Date Published:
- Journal Name:
- Biosensors and bioelectronics
- Volume:
- 178
- Issue:
- 2021
- ISSN:
- 2590-1370
- Page Range / eLocation ID:
- 113011
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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Abstract Elucidating the sources of a microbiome can provide insight into the ecological dynamics responsible for the formation of these communities. Source tracking approaches to date leverage species abundance information; however, single nucleotide variants (SNVs) may be more informative because of their high specificity to certain sources. To overcome the computational burden of utilizing all SNVs for a given sample, we introduce a novel method to identify signature SNVs for source tracking. Signature SNVs used as input into a previously designed source tracking algorithm, FEAST, can more accurately estimate contributions than species and provide novel insights, demonstrated in three case studies.