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   https://doi.org/10.1039/D3SC01936E  

   Newton, Turner D.; Li, Keyan; Sharma, Jyoti; Champagne, Pier Alexandre; Pluth, Michael D. (July 2023, Chemical Science)

   Mechanistic differences in S/Se chemistry enable direct H₂Se release from selenocarbamates. 

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2. Cysteine-activated hydrogen selenide (H ₂ Se) delivery from isoselenocyanates

   https://doi.org/10.1039/D5CC05352H  

   Dorit, Reis D; Li, Keyan; Steven, Christopher A; Garcia, Arman C; Newton, Turner D; Fosnacht, Kaylin G; Pluth, Michael D (October 2025, Chemical Communications)

   Hydrogen selenide (H2Se) is an emerging bioregulator and precursor to essential selenium-containing biomolecules. We show that aryl isoselenocyanates (ISeC-R) release H2Se upon activation by cysteine, and that electronic substitution can modulate release profiles. We also demonstrate applications to live cell imaging, expanding available tools for investigating H2Se chemical biology. 

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3. Development of a hydrolysis-based small-molecule hydrogen selenide (H ₂ Se) donor

   https://doi.org/10.1039/c9sc04616j  

   Newton, Turner D.; Pluth, Michael D. (November 2019, Chemical Science)

   Selenium is essential to human physiology and has recently shown potential in the treatment of common pathophysiological conditions ranging from arsenic poisoning to cancer. Although the precise metabolic and chemical pathways of selenium incorporation into biomolecules remain somewhat unclear, many such pathways proceed through hydrogen selenide (H 2 Se/HSe − ) formation. Despite this importance, well-characterized chemistry that enables H 2 Se release under controlled conditions remains lacking. Motivated by this need, we report here the development of a hydrolysis-based H 2 Se donor (TDN1042). Utilizing 31 P and 77 Se NMR experiments, we demonstrate the pH dependence of H 2 Se release and characterize observed reaction intermediates during the hydrolysis mechanism. Finally, we confirm H 2 Se release using electrophilic trapping reagents, which not only demonstrates the fidelity of this donor platform but also provides an efficient method for investigating future H 2 Se donor motifs. Taken together, this work provides an early example of an H 2 Se donor that functions through a well-defined and characterized mechanism. 

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4. Dibridged, Monobridged, Vinylidene-Like, and Linear Structures for the Alkaline Earth Dihydrides Be ₂ H ₂ , Mg ₂ H ₂ , Ca ₂ H ₂ , Sr ₂ H ₂ , and Ba ₂ H ₂ . Proposals for Observations

   https://doi.org/10.1021/acs.inorgchem.0c01651  

   Narendrapurapu, Beulah S.; Bowman, Michael C.; Xie, Yaoming; Schaefer, Henry F.; Tkachenko, Nikolay V.; Boldyrev, Alexander I.; Li, Guoliang (August 2020, Inorganic Chemistry)
5. Healing Se Vacancies in Bi ₂ Se ₃ by Ambient Gases

   https://doi.org/10.1021/acs.jpcc.2c05175  

   Shirodkar, Sharmila N.; Stephen, Gregory M.; Hanbicki, Aubrey T.; Friedman, Adam L.; Dev, Pratibha (October 2022, The Journal of Physical Chemistry C)