More Like this

1. A Distinctive Platform System to Study the Effects of a Vestibular Prosthesis on Nonhuman Primate Postural Control

   https://doi.org/10.1115/1.4039140  

   Thompson, Lara A.; Haburcakova, Csilla; Lewis, Richard F. (May 2018, Journal of Engineering and Science in Medical Diagnostics and Therapy)

   The purpose of this paper is to describe novel experiments and methodologies utilizing a distinctive balance platform system to investigate postural responses for moderate to severe vestibular loss and invasive vestibular prosthesis-assisted nonhuman primates (rhesus monkeys). For several millions of vestibular loss sufferers in the U.S., daily living is severely affected in that common everyday tasks, such as getting out of bed at night, maintaining balance on a moving bus, or walking on an uneven surface, may cause a loss of stability leading to falls and injury. Aside from loss of balance, blurred vision and vertigo (perceived spinning sensation) are also debilitating in vestibular-impaired individuals. Although the need for vestibular rehabilitative solutions is apparent, postural responses for a broad range of peripheral vestibular function, and for various stationary and moving support conditions, have not been systematically investigated. For the investigation of implants and prostheses that are being developed toward implementation in humans, nonhuman primates are a key component. The measurement system used in this research was unique. Our platform system facilitated the study of rhesus monkey posture for stationary support surface conditions (quiet stance and head turns) and for dynamic support surface conditions (pseudorandom roll tilts of the support surface). Further, the platform system was used to systematically study postural responses that will serve as baseline measures for future vestibular-focused human and nonhuman primate posture studies. 

   more » « less
2. Sensory prosthetics - clinical and scientific utility of a vestibular implant

   Haburcakova, C.; Merfeld, D.; Gong, W.; Guinand, N.; Perez, Fornos A.; Thompson, L.A.; Guyot, J.P.; Lewis, R.F. (April 2017, Neurology)

   Objective: To determine if a vestibular prosthesis could improve function in subjects with severe vestibular damage and could be used it as a scientific tool to investigate central vestibular processing. Background: Damage to the vestibular labyrinth is common and usually permanent. We therefore developed and tested a vestibular implant (VI) that is designed to mimic the information normally provided by the vestibular labyrinth to determine if we can reduce vestibular-mediated deficits and study temporal integration of sensory cues in the brain. Design/Methods: Monkeys had electrodes implanted in the semicircular canals of one ear and then severe bilateral vestibular damage was induced with aminoglycosides. Eye movements, perception, and balance were tested before and after vestibular damage and with the VI activated, which supplied head motion information to the brain via electrical stimulation delivered by the implanted electrodes. Humans also had electrode implantation (done in conjunction with a cochlear implant, CI) and they were tested on a temporal binding psychophysical task Results: Stimulation provided by VI in vestibulopathic monkeys improved their balance, perception of spatial orientation, and eye movement responses. Timing experiments in humans using CI and VI stimuli showed that unlike past experiments that used motion to generate the vestibular signal, CI and VI signals were received by the cerebral cortex with the same latency and were perceived as simultaneous, but this timing perception was highly sensitive to adaption. Conclusions: VI improves oculomotor, postural, and perceptual behavior in vestibulopathic monkeys and could prove to be an effective way to improve these functions in patients with permanent labyrinthine damage. Timing experiments show that when novel stimuli are used, the brain synthesizes them in accordance with their arrival at the cortex, but that experience can rapidly recalibrate this timing relationship, which may be why normal stimuli that are experienced habitually lack this characteristic. 

   more » « less
3. Experiential Learning for Interdisciplinary Education on Vestibular System Models

   Nia, M.F.; Callen, G.E.; An, J.; Chandra, K.; Thompson, C.; Wolkowicz, K.; Denis, M. (April 2023, ASEE annual conference exposition)

   The vestibular system (VS) allows humans to have a sense of balance and orientation. Within the VS, fluid displacement occurs within the ear canal, triggering nerve signals to be translated by the nervous system, allowing for the interpretation of the head's orientation. When there is a disturbance to this system, vestibular dysfunction occurs potentially causing vertigo and a loss of. balance. It is estimated that 35 percent of adults 40 years or older in the United States have experienced vestibular dysfunction. The vestibular balance system poses a robust, unique topic for developing interdisciplinary education curricula as its function encapsulates many fundamental mechanical, chemical, biological, and physical phenomena that can be studied with engineering concepts and principles. In this work, we present a survey of models of the vestibular sensory system. Following which, selected models are presented in an experiential learning format for students to better understand the relationship and sensitivity of model parameters and external stimuli to physiological system behavior. By conducting simulations of these models, students can visualize outcomes, pose questions, and potentially identify areas of research interest. This paper is the outcome of an Innovations in Graduate Education project supported by the National Science Foundation. The authors are graduate students from three engineering majors from the University of Massachusetts Lowell and the University of the District of Columbia co-creating an educational module with faculty and experts on human balance. The developed module related to analyzing the vestibular balance system mechanics will be integrated into undergraduate courses across engineering departments in partnering institutions. 

   more » « less
4. Experiential Learning for Interdisciplinary Education on Vestibular System Models

   Nia, M.F.; Callen, G.E.; Aroskar, G.; An, J.; Chandra, K.; Thompson, C.; Wolkowicz, K.; Denis, M. (June 2023, Proceedings of the 2023 ASEE Annual Conference & Exposition)

   The vestibular system (VS) allows humans to have a sense of balance and orientation. Within the VS, fluid displacement occurs within the ear canal, triggering nerve signals to be translated by the nervous system, allowing for the interpretation of the head's orientation. When there is a disturbance to this system, vestibular dysfunction occurs potentially causing vertigo and a loss of balance. It is estimated that 35 percent of adults 40 years or older in the United States have experienced vestibular dysfunction. The vestibular balance system poses a robust, unique topic for developing interdisciplinary education curricula as its function encapsulates many fundamental mechanical, chemical, biological, and physical phenomena that can be studied with engineering concepts and principles. In this work, we present a survey of models of the vestibular sensory system. Following which, selected models are presented in an experiential learning format for students to better understand the relationship and sensitivity of model parameters and external stimuli to physiological system behavior. By conducting simulations of these models, students can visualize outcomes, pose questions, and potentially identify areas of research interest. This paper is the outcome of an Innovations in Graduate Education project supported by the National Science Foundation. The authors are graduate students from three engineering majors from the University of Massachusetts Lowell and the University of the District of Columbia co-creating an educational module with faculty and experts on human balance. The developed module related to analyzing the vestibular balance system mechanics will be integrated into undergraduate courses across engineering departments in partnering institutions. 

   more » « less
5. Gyroscopic Balancer-Enhanced Motion Control of an Autonomous Bikebot

   https://doi.org/10.1115/1.4063014  

   Wang, Pengcheng; Han, Feng; Yi, Jingang (October 2023, Journal of Dynamic Systems, Measurement, and Control)

   Abstract Bikebot (i.e., bicycle-based robot) is a class of underactuated balance robotic systems that require simultaneous trajectory tracking and balance control tasks. We present a tracking and balance control design of an autonomous bikebot. The external-internal convertible structure of the bikebot dynamics is used to design a causal feedback control to achieve both the tracking and balance tasks. A balance equilibrium manifold is used to define and capture the platform balance profiles and coupled interaction with the trajectory tracking performance. To achieve fully autonomous navigation, a gyrobalancer actuation is integrated with the steering and velocity control for stationary platform balance and stationary-moving switching. Stability and convergence analyses are presented to guarantee the control performance. Extensive experiments are presented to validate and demonstrate the autonomous control design. We also compare the autonomous control performance with human riding experiments and similar action strategies are found between them. 

   more » « less