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  • THEORETICAL, COMPUTATIONAL AND EXPERIMENTAL CHARACTERIZATION OF SHEAR-DEPENDENT MICRO-VORTICES IN LIQUID—LIQUID FLOW-FOCUSING GEOMETRY
Title: THEORETICAL, COMPUTATIONAL AND EXPERIMENTAL CHARACTERIZATION OF SHEAR-DEPENDENT MICRO-VORTICES IN LIQUID—LIQUID FLOW-FOCUSING GEOMETRY
In this work, we apply theoretical, computational and experimental fluid dynamics to characterize hydrodynamics micro-vortices formation in the dispersed phase at the flow-focusing microfluidic droplet generation junction. This interfacial hydrodynamic method can be exploited to trap cells inside the micro-vortices and later release them in a one-to-one manner to achieve high efficiency single-cell encapsulation inside droplets. This passive trap and release mechanism is controlled by the distance between the closed vortex streamline and the liquid-liquid interface (dgap) and, thus, fundamental understanding of the micro-vortices and parameters affecting their formation, trajectory and magnitude is necessary to achieve effective one-to-one encapsulation.  more » « less
Award ID(s):
1841509
PAR ID:
10316889
Author(s) / Creator(s):
Date Published:
Journal Name:
The 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2021)
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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