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1. Exploiting Switching of Transistors in Digital Electronics for RFID Tag Design

   C-L Cheng, L. N. ( June 2019 , IEEE journal of radio frequency identification)

   Existing analog-signal side-channels, such as EM emanations, are a consequence of current-flow changes that are dependent on activity inside an electronic circuits. In this paper, we introduce a new class of side-channels that is a consequence of impedance changes in switching circuits, and we refer to it as an impedance-based side-channel. One example of such a side-channel is when digital logic activity causes incoming EM signals to be modulated as they are reflected (backscattered), at frequencies that depend on both the incoming EM signal and the circuit activity. This can cause EM interference or leakage of sensitive information, but it can also be leveraged for RFID tag design. In this paper, we first introduce a new class of side-channels that is a consequence of impedance differences in switching circuits, and we refer to it as an impedance-based side-channel. Then, we demonstrate that the impedance difference between transistor gates in the high-state and in the low-state changes the radar cross section (RCS) and modulates the backscattered signal. Furthermore, we have investigated the possibility of implementing the proposed RFID on ASIC for signal enhancement. Finally, we propose a digital circuit that can be used as a semi-passive RFID tag. To illustrate the adaptability of the proposed RFID, we have designed a variety of RFID applications across carrier frequencies at 5.8 GHz, 17.46 GHz, and 26.5 GHz to demonstrate flexible carrier frequency selection and bit configuration. 

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2. 29.8 SHARC: Self-Healing Analog with RRAM and CNFETs

   https://doi.org/10.1109/ISSCC.2019.8662377  

   Amer, Aya G. ; Ho, Rebecca ; Hills, Gage ; Chandrakasan, Anantha P. ; Shulaker, Max M. ( February 2019 , SHARC: Self-Healing Analog with RRAM and CNFETs)

   Carbon nanotube (CNT) field-effect transistors (CNFETs) are a promising emerging technology for energy-efficient electronics (Fig. 1). Despite this promise, CNTs are subject to substantial inherent imperfections; every ensemble of CNTs includes some percentage of metallic CNTs (m-CNTs). m-CNTs result in conductive shorts between CNFET source and drain, resulting in excessive leakage and degraded (potentially incorrect) circuit functionality (Fig. 1). Several techniques have been developed to remove the majority of m-CNTs (no technique today removes 100% of m-CNTs). While these techniques enabled the first digital CNFET circuits, it is still not possible to realize large-scale CNFET analog or mixed-signal CNFET circuits due to m-CNTs. As shown in Fig. 1, while a digital logic gate can still function correctly in the presence of a small fraction of m-CNTs (but with degraded resilience to noise) [1], a single m-CNT in an analog circuit can result in catastrophic failure (e.g., degrading amplifier gain resulting in functional failure of circuit blocks such as ADCs and DACs)1. This paper presents a circuit design technique, Self-Healing Analog with RRAM and CNFETs (SHARC), that leverages the programmability of non-volatile resistive RAM (RRAM) to automatically “self-heal” analog circuits in the presence of m-CNTs. Using SHARC, we experimentally demonstrate analog CNFET circuits robust to m-CNTs as well as the first mixed-signals CNFET subsystem (4-bit DAC and SAR ADC; these are the largest reported complementary (CMOS) CNFET circuit demonstrations to-date). 

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3. Sound Source Localization Using Stochastic Computing

   https://doi.org/10.1145/3508352.3549373  

   Schober, Peter ; Estiri, Seyedeh Newsha ; Aygun, Sercan ; TaheriNejad, Nima ; Najafi, M. Hassan ( October 2022 , 41st IEEE/ACM International Conference on Computer-Aided Design)

   Stochastic computing (SC) is an alternative computing paradigm that possesses data in the form of long uniform bit-streams rather than conventional compact weighted binary numbers. SC is fault-tolerant and can compute on small, efficient circuits, promising advantages over conventional arithmetic for smaller computer chips. SC has been primarily used in scientific research, not in practical applications. Digital sound source localization (SSL) is a useful signal processing technique that locates speakers using multiple microphones in cell phones, laptops, and other voice-controlled devices. SC has not been integrated into SSL in practice or theory. In this work, for the first time to the best of our knowledge, we implement an SSL algorithm in the stochastic domain and develop a functional SC-based sound source localizer. The developed design can replace the conventional design of the algorithm. The practical part of this work shows that the proposed stochastic circuit does not rely on conventional analog-to-digital conversion and can process data in the form of pulss-width-mudulated (PWM) signals. 

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4. The Temple University Digital Pathology Corpus: The Breast Tissue Subset

   https://doi.org/10.1109/SPMB52430.2021.9672275  

   Wevodau, Z. ; Doshna, B. ; Jhala, N. ; Akhtar, I. ; Obeid, I. ; Picone, J. ( December 2021 , Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB))

   Obeid, I. (Ed.)

   The Neural Engineering Data Consortium (NEDC) is developing the Temple University Digital Pathology Corpus (TUDP), an open source database of high-resolution images from scanned pathology samples [1], as part of its National Science Foundation-funded Major Research Instrumentation grant titled “MRI: High Performance Digital Pathology Using Big Data and Machine Learning” [2]. The long-term goal of this project is to release one million images. We have currently scanned over 100,000 images and are in the process of annotating breast tissue data for our first official corpus release, v1.0.0. This release contains 3,505 annotated images of breast tissue including 74 patients with cancerous diagnoses (out of a total of 296 patients). In this poster, we will present an analysis of this corpus and discuss the challenges we have faced in efficiently producing high quality annotations of breast tissue. It is well known that state of the art algorithms in machine learning require vast amounts of data. Fields such as speech recognition [3], image recognition [4] and text processing [5] are able to deliver impressive performance with complex deep learning models because they have developed large corpora to support training of extremely high-dimensional models (e.g., billions of parameters). Other fields that do not have access to such data resources must rely on techniques in which existing models can be adapted to new datasets [6]. A preliminary version of this breast corpus release was tested in a pilot study using a baseline machine learning system, ResNet18 [7], that leverages several open-source Python tools. The pilot corpus was divided into three sets: train, development, and evaluation. Portions of these slides were manually annotated [1] using the nine labels in Table 1 [8] to identify five to ten examples of pathological features on each slide. Not every pathological feature is annotated, meaning excluded areas can include focuses particular to these labels that are not used for training. A summary of the number of patches within each label is given in Table 2. To maintain a balanced training set, 1,000 patches of each label were used to train the machine learning model. Throughout all sets, only annotated patches were involved in model development. The performance of this model in identifying all the patches in the evaluation set can be seen in the confusion matrix of classification accuracy in Table 3. The highest performing labels were background, 97% correct identification, and artifact, 76% correct identification. A correlation exists between labels with more than 6,000 development patches and accurate performance on the evaluation set. Additionally, these results indicated a need to further refine the annotation of invasive ductal carcinoma (“indc”), inflammation (“infl”), nonneoplastic features (“nneo”), normal (“norm”) and suspicious (“susp”). This pilot experiment motivated changes to the corpus that will be discussed in detail in this poster presentation. To increase the accuracy of the machine learning model, we modified how we addressed underperforming labels. One common source of error arose with how non-background labels were converted into patches. Large areas of background within other labels were isolated within a patch resulting in connective tissue misrepresenting a non-background label. In response, the annotation overlay margins were revised to exclude benign connective tissue in non-background labels. Corresponding patient reports and supporting immunohistochemical stains further guided annotation reviews. The microscopic diagnoses given by the primary pathologist in these reports detail the pathological findings within each tissue site, but not within each specific slide. The microscopic diagnoses informed revisions specifically targeting annotated regions classified as cancerous, ensuring that the labels “indc” and “dcis” were used only in situations where a micropathologist diagnosed it as such. Further differentiation of cancerous and precancerous labels, as well as the location of their focus on a slide, could be accomplished with supplemental immunohistochemically (IHC) stained slides. When distinguishing whether a focus is a nonneoplastic feature versus a cancerous growth, pathologists employ antigen targeting stains to the tissue in question to confirm the diagnosis. For example, a nonneoplastic feature of usual ductal hyperplasia will display diffuse staining for cytokeratin 5 (CK5) and no diffuse staining for estrogen receptor (ER), while a cancerous growth of ductal carcinoma in situ will have negative or focally positive staining for CK5 and diffuse staining for ER [9]. Many tissue samples contain cancerous and non-cancerous features with morphological overlaps that cause variability between annotators. The informative fields IHC slides provide could play an integral role in machine model pathology diagnostics. Following the revisions made on all the annotations, a second experiment was run using ResNet18. Compared to the pilot study, an increase of model prediction accuracy was seen for the labels indc, infl, nneo, norm, and null. This increase is correlated with an increase in annotated area and annotation accuracy. Model performance in identifying the suspicious label decreased by 25% due to the decrease of 57% in the total annotated area described by this label. A summary of the model performance is given in Table 4, which shows the new prediction accuracy and the absolute change in error rate compared to Table 3. The breast tissue subset we are developing includes 3,505 annotated breast pathology slides from 296 patients. The average size of a scanned SVS file is 363 MB. The annotations are stored in an XML format. A CSV version of the annotation file is also available which provides a flat, or simple, annotation that is easy for machine learning researchers to access and interface to their systems. Each patient is identified by an anonymized medical reference number. Within each patient’s directory, one or more sessions are identified, also anonymized to the first of the month in which the sample was taken. These sessions are broken into groupings of tissue taken on that date (in this case, breast tissue). A deidentified patient report stored as a flat text file is also available. Within these slides there are a total of 16,971 total annotated regions with an average of 4.84 annotations per slide. Among those annotations, 8,035 are non-cancerous (normal, background, null, and artifact,) 6,222 are carcinogenic signs (inflammation, nonneoplastic and suspicious,) and 2,714 are cancerous labels (ductal carcinoma in situ and invasive ductal carcinoma in situ.) The individual patients are split up into three sets: train, development, and evaluation. Of the 74 cancerous patients, 20 were allotted for both the development and evaluation sets, while the remain 34 were allotted for train. The remaining 222 patients were split up to preserve the overall distribution of labels within the corpus. This was done in hope of creating control sets for comparable studies. Overall, the development and evaluation sets each have 80 patients, while the training set has 136 patients. In a related component of this project, slides from the Fox Chase Cancer Center (FCCC) Biosample Repository (https://www.foxchase.org/research/facilities/genetic-research-facilities/biosample-repository -facility) are being digitized in addition to slides provided by Temple University Hospital. This data includes 18 different types of tissue including approximately 38.5% urinary tissue and 16.5% gynecological tissue. These slides and the metadata provided with them are already anonymized and include diagnoses in a spreadsheet with sample and patient ID. We plan to release over 13,000 unannotated slides from the FCCC Corpus simultaneously with v1.0.0 of TUDP. Details of this release will also be discussed in this poster. Few digitally annotated databases of pathology samples like TUDP exist due to the extensive data collection and processing required. The breast corpus subset should be released by November 2021. By December 2021 we should also release the unannotated FCCC data. We are currently annotating urinary tract data as well. We expect to release about 5,600 processed TUH slides in this subset. We have an additional 53,000 unprocessed TUH slides digitized. Corpora of this size will stimulate the development of a new generation of deep learning technology. In clinical settings where resources are limited, an assistive diagnoses model could support pathologists’ workload and even help prioritize suspected cancerous cases. ACKNOWLEDGMENTS This material is supported by the National Science Foundation under grants nos. CNS-1726188 and 1925494. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. REFERENCES [1] N. Shawki et al., “The Temple University Digital Pathology Corpus,” in Signal Processing in Medicine and Biology: Emerging Trends in Research and Applications, 1st ed., I. Obeid, I. Selesnick, and J. Picone, Eds. New York City, New York, USA: Springer, 2020, pp. 67 104. https://www.springer.com/gp/book/9783030368432. [2] J. Picone, T. Farkas, I. Obeid, and Y. Persidsky, “MRI: High Performance Digital Pathology Using Big Data and Machine Learning.” Major Research Instrumentation (MRI), Division of Computer and Network Systems, Award No. 1726188, January 1, 2018 – December 31, 2021. https://www. isip.piconepress.com/projects/nsf_dpath/. [3] A. Gulati et al., “Conformer: Convolution-augmented Transformer for Speech Recognition,” in Proceedings of the Annual Conference of the International Speech Communication Association (INTERSPEECH), 2020, pp. 5036-5040. https://doi.org/10.21437/interspeech.2020-3015. [4] C.-J. Wu et al., “Machine Learning at Facebook: Understanding Inference at the Edge,” in Proceedings of the IEEE International Symposium on High Performance Computer Architecture (HPCA), 2019, pp. 331–344. https://ieeexplore.ieee.org/document/8675201. [5] I. Caswell and B. Liang, “Recent Advances in Google Translate,” Google AI Blog: The latest from Google Research, 2020. [Online]. Available: https://ai.googleblog.com/2020/06/recent-advances-in-google-translate.html. [Accessed: 01-Aug-2021]. [6] V. Khalkhali, N. Shawki, V. Shah, M. Golmohammadi, I. Obeid, and J. Picone, “Low Latency Real-Time Seizure Detection Using Transfer Deep Learning,” in Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB), 2021, pp. 1 7. https://www.isip. piconepress.com/publications/conference_proceedings/2021/ieee_spmb/eeg_transfer_learning/. [7] J. Picone, T. Farkas, I. Obeid, and Y. Persidsky, “MRI: High Performance Digital Pathology Using Big Data and Machine Learning,” Philadelphia, Pennsylvania, USA, 2020. https://www.isip.piconepress.com/publications/reports/2020/nsf/mri_dpath/. [8] I. Hunt, S. Husain, J. Simons, I. Obeid, and J. Picone, “Recent Advances in the Temple University Digital Pathology Corpus,” in Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB), 2019, pp. 1–4. https://ieeexplore.ieee.org/document/9037859. [9] A. P. Martinez, C. Cohen, K. Z. Hanley, and X. (Bill) Li, “Estrogen Receptor and Cytokeratin 5 Are Reliable Markers to Separate Usual Ductal Hyperplasia From Atypical Ductal Hyperplasia and Low-Grade Ductal Carcinoma In Situ,” Arch. Pathol. Lab. Med., vol. 140, no. 7, pp. 686–689, Apr. 2016. https://doi.org/10.5858/arpa.2015-0238-OA. 

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5. Passive impedance-loaded surface acoustic wave (SAW) sensor for soil condition monitoring

   Chu, Jian ; Voiculescu, Ioana ; Dong, Ziqian ; Li, Fang ( February 2021 , Proc. ASME. IMECE2020)

   null (Ed.)

   This paper presents an innovative system to monitor the physical soil conditions needed for modern agriculture. The current technique to measure soil properties relies on taking samples from place to place and takes them for laboratory testing. To build up and monitor a data-based system for a large area, such a method is costly and time-consuming. This paper reported our recent work on the development of a passive impedance-loaded surface acoustic wave (SAW) sensor for a low-cost soil condition monitoring system. The SAW sensor will eventually be connected to an antenna and a impedance-based sensor for autonomous soil nutrient sensing. In this research, first, the coupling-of-modes (COM) analysis was performed to simulate the SAW device. The sensors were fabricated with E-beam lithography techniques and tested with different external load resistances. We investigated how the sensor signal changed with the external resistance loading. The experimental results were verified by comparing them with simulation results. 

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