Abstract Sustained attention is a critical cognitive function reflected in an individual’s whole-brain pattern of functional magnetic resonance imaging functional connectivity. However, sustained attention is not a purely static trait. Rather, attention waxes and wanes over time. Do functional brain networks that underlie individual differences in sustained attention also underlie changes in attentional state? To investigate, we replicate the finding that a validated connectome-based model of individual differences in sustained attention tracks pharmacologically induced changes in attentional state. Specifically, preregistered analyses revealed that participants exhibited functional connectivity signatures of stronger attention when awake than when under deep sedation with the anesthetic agent propofol. Furthermore, this effect was relatively selective to the predefined sustained attention networks: propofol administration modulated strength of the sustained attention networks more than it modulated strength of canonical resting-state networks and a network defined to predict fluid intelligence, and the functional connections most affected by propofol sedation overlapped with the sustained attention networks. Thus, propofol modulates functional connectivity signatures of sustained attention within individuals. More broadly, these findings underscore the utility of pharmacological intervention in testing both the generalizability and specificity of network-based models of cognitive function.
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Neural signatures of attentional engagement during narratives and its consequences for event memory
As we comprehend narratives, our attentional engagement fluctuates over time. Despite theoretical conceptions of narrative engagement as emotion-laden attention, little empirical work has characterized the cognitive and neural processes that comprise subjective engagement in naturalistic contexts or its consequences for memory. Here, we relate fluctuations in narrative engagement to patterns of brain coactivation and test whether neural signatures of engagement predict subsequent memory. In behavioral studies, participants continuously rated how engaged they were as they watched a television episode or listened to a story. Self-reported engagement was synchronized across individuals and driven by the emotional content of the narratives. In functional MRI datasets collected as different individuals watched the same show or listened to the same story, engagement drove neural synchrony, such that default mode network activity was more synchronized across individuals during more engaging moments of the narratives. Furthermore, models based on time-varying functional brain connectivity predicted evolving states of engagement across participants and independent datasets. The functional connections that predicted engagement overlapped with a validated neuromarker of sustained attention and predicted recall of narrative events. Together, our findings characterize the neural signatures of attentional engagement in naturalistic contexts and elucidate relationships among narrative engagement, sustained attention, and event memory.
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- Award ID(s):
- 2043740
- NSF-PAR ID:
- 10321880
- Date Published:
- Journal Name:
- Proceedings of the National Academy of Sciences
- Volume:
- 118
- Issue:
- 33
- ISSN:
- 0027-8424
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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The ability to sustain attention differs across people and changes within a single person over time. Although recent work has demonstrated that patterns of functional brain connectivity predict individual differences in sustained attention, whether these same patterns capture fluctuations in attention within individuals remains unclear. Here, across five independent studies, we demonstrate that the sustained attention connectome-based predictive model (CPM), a validated model of sustained attention function, generalizes to predict attentional state from data collected across minutes, days, weeks, and months. Furthermore, the sustained attention CPM is sensitive to within-subject state changes induced by propofol as well as sevoflurane, such that individuals show functional connectivity signatures of stronger attentional states when awake than when under deep sedation and light anesthesia. Together, these results demonstrate that fluctuations in attentional state reflect variability in the same functional connectivity patterns that predict individual differences in sustained attention.
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Abstract Are the brain bases of language comprehension the same across all human languages, or do these bases vary in a way that corresponds to differences in linguistic typology? English and Mandarin Chinese attest such a typological difference in the domain of relative clauses. Using functional magnetic resonance imaging with English and Chinese participants, who listened to the same translation-equivalent story, we analyzed neuroimages time aligned to object-extracted relative clauses in both languages. In a general linear model analysis of these naturalistic data, comprehension was selectively associated with increased hemodynamic activity in left posterior temporal lobe, angular gyrus, inferior frontal gyrus, precuneus, and posterior cingulate cortex in both languages. This result suggests the processing of object-extracted relative clauses is subserved by a common collection of brain regions, regardless of typology. However, there were also regions that were activated uniquely in our Chinese participants albeit not to a significantly greater degree. These were in the temporal lobe. These Chinese-specific results could reflect structural ambiguity-resolution work that must be done in Chinese but not English object-extracted relative clauses.
- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1073/pnas.2021905118
