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Title: Involvement of RNA granule proteins in meiotic silencing by unpaired DNA
Abstract In Neurospora crassa, expression from an unpaired gene is suppressed by a mechanism known as meiotic silencing by unpaired DNA (MSUD). MSUD utilizes common RNA interference (RNAi) factors to silence target mRNAs. Here, we report that Neurospora CAR-1 and CGH-1, homologs of two Caenorhabditis elegans RNA granule components, are involved in MSUD. These fungal proteins are found in the perinuclear region and P-bodies, much like their worm counterparts. They interact with components of the meiotic silencing complex (MSC), including the SMS-2 Argonaute. This is the first time MSUD has been linked to RNA granule proteins.
Authors:
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Award ID(s):
1715534
Publication Date:
NSF-PAR ID:
10323936
Journal Name:
G3 Genes|Genomes|Genetics
Volume:
11
Issue:
10
ISSN:
2160-1836
Sponsoring Org:
National Science Foundation
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