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Title: Encapsulation of closo -dodecaiodododecaborate in 2-hydroxypropyl-γ-cyclodextrin prevents hemolysis
Na 2 B 12 I 12 has many of the properties desired by an X-ray contrast agent but is lethal at the concentrations needed for medical imaging. We demonstrate here that PBS solutions with >50 mM Na 2 B 12 I 12 induce hemolysis, consistent with the previously reported superchaotropic nature of the anion. The presence of <1 equiv. of 2-hydroxypropyl-γ-cyclodextrin prevents hemolysis and suggests a strategy for exploiting B 12 I 12 2− as an X-ray contrast agent.  more » « less
Award ID(s):
2018501
PAR ID:
10332153
Author(s) / Creator(s):
;
Date Published:
Journal Name:
Chemical Communications
Volume:
58
Issue:
14
ISSN:
1359-7345
Page Range / eLocation ID:
2375 to 2378
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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