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Title: Quantitative Surface-Enhanced Spectroscopy
Surface-enhanced Raman scattering (SERS), a powerful technique for trace molecular detection, depends on chemical and electromagnetic enhancements. While recent advances in instrumentation and substrate design have expanded the utility, reproducibility, and quantitative capabilities of SERS, some challenges persist. In this review, advances in quantitative SERS detection are discussed as they relate to intermolecular interactions, surface selection rules, and target molecule solubility and accessibility. After a brief introduction to Raman scattering and SERS, impacts of surface selection rules and enhancement mechanisms are discussed as they relate to the observation of activation and deactivation of normal Raman modes in SERS. Next, experimental conditions that can be used to tune molecular affinity to and density near SERS substrates are summarized and considered while tuning these parameters is conveyed. Finally, successful examples of quantitative SERS detection are discussed, and future opportunities are outlined.  more » « less
Award ID(s):
1707859
PAR ID:
10337129
Author(s) / Creator(s):
; ; ;
Date Published:
Journal Name:
Annual Review of Physical Chemistry
Volume:
73
Issue:
1
ISSN:
0066-426X
Page Range / eLocation ID:
141 to 162
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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