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Title: T cell immune responses deciphered
An immune response involves a coordinated orchestra of antigen-recognizing cells ( e.g. , T cells) and signaling molecules to mount a specific response against a pathogen. Although systems immunology offers a growing list of molecular interactions that are involved in antigen-specific immune responses, an understanding of how a response is mediated by different antigen characteristics is still lacking. On page 880 of this issue, Achar et al. ( 1 ) address this question by using a robotic platform to survey a broad range of functional T cell responses to different antigen stimulations. Using machine learning, they construct a simplified map that separates six different stereotypical classes of antigen-dependent immune responses. Understanding this antigen-encoding could help guide immunotherapy, including engineering chimeric antigen receptor (CAR)–T cells and identifying vaccine antigens.  more » « less
Award ID(s):
2045054
PAR ID:
10337466
Author(s) / Creator(s):
Date Published:
Journal Name:
Science
Volume:
376
Issue:
6595
ISSN:
0036-8075
Page Range / eLocation ID:
796 to 797
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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