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1. Location, location, location: considerations when using lightweight drones in challenging environments

   https://doi.org/10.1002/rse2.58  

   Duffy, James P. ; Cunliffe, Andrew M. ; DeBell, Leon ; Sandbrook, Chris ; Wich, Serge A. ; Shutler, Jamie D. ; Myers-Smith, Isla H. ; Varela, Miguel R. ; Anderson, Karen ; Pettorelli, Nathalie ; et al ( March 2018 , Remote Sensing in Ecology and Conservation)
2. Location, location, location: The effects of place in place-based simulations

   Siebert-Evenstone, A. L ; Shaffer, D. W. ( January 2019 , A Wide Lens: Combining Embodied, Enactive, Extended, and Embedded Learning in Collaborative Settings:13th International Conference on Computer Supported Collaborative Learning)
3. Location, location, location: the organization and roles of potassium channels in mammalian motoneurons

   https://doi.org/10.1113/JP278675  

   Deardorff, Adam S. ; Romer, Shannon H. ; Fyffe, Robert E. W. ( January 2021 , The Journal of Physiology)

   The spatial and temporal balance of spinal α‐motoneuron (αMN) intrinsic membrane conductances underlies the neural output of the final common pathway for motor commands. Although the complete set and precise localization of αMN K⁺channels and their respective outward conductances remain unsettled, important K⁺channel subtypes have now been documented, including Kv1, Kv2, Kv7, TASK, HCN and SK isoforms. Unique kinetics and gating parameters allow these channels to differentially shape and/or modify αMN firing properties, and recent immunohistochemical localization of K⁺‐channel complexes reveals a framework in which their spatial distribution and/or focal clustering within different surface membrane compartments is highly tuned to their physiological function. Moreover, highly evolved regulatory mechanisms enable specific channels to operate over variable levels of αMN activity and contribute to either state‐dependent enhancement or diminution of firing. While recent data suggest an additional, non‐conducting role for clustered Kv2.1 channels in the formation of endoplasmic reticulum–plasma membrane junctions postsynaptic to C‐bouton synapses, electrophysiological evidence demonstrates that conducting Kv2.1 channels effectively regulate αMN firing, especially during periods of high activity in which the cholinergic C‐boutons are engaged. Intense αMN activity or cell injury rapidly disrupts the clustered organization of Kv2.1 channels in αMNs and further impacts their physiological role. Thus, αMN K⁺channels play a critical regulatory role in motor processing and are potential therapeutic targets for diseases affecting αMN excitability and motor output, including amyotrophic lateral sclerosis.image

    

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4. Location, location! cellular relocalization primes specialized metabolic diversification

   https://doi.org/10.1111/febs.15097  

   Schenck, Craig A. ; Last, Robert L. ( November 2019 , The FEBS Journal)

   Specialized metabolites are structurally diverse and cell‐ or tissue‐specific molecules produced in restricted plant lineages. In contrast, primary metabolic pathways are highly conserved in plants and produce metabolites essential for all of life, such as amino acids and nucleotides. Substrate promiscuity – the capacity to accept non‐native substrates – is a common characteristic of enzymes, and its impact is especially apparent in generating specialized metabolite variation. However, promiscuity only leads to metabolic diversity when alternative substrates are available; thus, enzyme cellular and subcellular localization directly influence chemical phenotypes. We review a variety of mechanisms that modulate substrate availability for promiscuous plant enzymes. We focus on examples where evolution led to modification of the ‘cellular context’ through changes in cell‐type expression, subcellular relocalization, pathway sequestration, and cellular mixing via tissue damage. These varied mechanisms contributed to the emergence of structurally diverse plant specialized metabolites and inform future metabolic engineering approaches.

    

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5. 'Location, Location, Location': An Exploration of Different Workplace Contexts in Remote Teamwork during the COVID-19 Pandemic

   https://doi.org/10.1145/3579504  

   Breideband, Thomas ; Moulder, Robert Glenn ; Martinez, Gonzalo J. ; Caruso, Megan ; Mark, Gloria ; Striegel, Aaron D. ; D'Mello, Sidney ( April 2023 , Proceedings of the ACM on Human-Computer Interaction: Computer Supported Collaborative Work)

   Much emphasis has been placed on how the affordances and layouts of an office setting can influence co-worker interactions and perceived team outcomes. Little is known, however, whether perceptions of teamwork and team conflict are affected when the location of work changes from the office to the home. To address this gap, we present findings from a ten-week,in situ study of 91 information workers from 27 US-based teams. We compare three distinct work locations---private and shared workspaces at home as well at the office---and explore how each location may impact individual perceptions of teamwork. While there was no significant association with participants' perceptions of teamwork, results revealed associations of work location with team conflict: participants who worked in a private room at home reported significantly lower team conflict compared to those working in the office. No difference was found for the office and the shared workspace. We further found that the influence of work location on team conflict interacted with job decision latitude and the level of task interdependence among co-workers. We discuss practical implications for full-time work from home (WFH) on teams. Our study adds an important environmental dimension to the literature on remote teaming, which in turn may help organizations as they consider, prepare, or implement more permanent WFH and/or hybrid work policies in the future.

    

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