The recent COVID-19 pandemic has propelled the field of aerosol science to the forefront, particularly the central role of virus-laden respiratory droplets and aerosols. The pandemic has also highlighted the critical need, and value for, an information bridge between epidemiological models (that inform policymakers to develop public health responses) and within-host models (that inform the public and health care providers how individuals develop respiratory infections). Here, we review existing data and models of generation of respiratory droplets and aerosols, their exhalation and inhalation, and the fate of infectious droplet transport and deposition throughout the respiratory tract. We then articulate how aerosol transport modeling can serve as a bridge between and guide calibration of within-host and epidemiological models, forming a comprehensive tool to formulate and test hypotheses about respiratory tract exposure and infection within and between individuals.
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Human Research Study of Particulate Propagation Distance From Human Respiratory Function
Abstract Background Airborne viral pathogens like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be encapsulated and transmitted through liquid droplets/aerosols formed during human respiratory events. Methods The number and extent of droplets/aerosols at distances between 1 and 6 ft (0.305–1.829 m) for a participant wearing no face covering, a cotton single-layer cloth face covering, and a 3-layer disposable face covering were measured for defined speech and cough events. The data include planar particle imagery to illuminate emissions by a light-sheet and local aerosol/droplet probes taken with phase Doppler interferometry and an aerodynamic particle sizer. Results Without face coverings, droplets/aerosols were detected up to a maximum of 1.25 m (4.1ft ± 0.22–0.28 ft) during speech and up to 1.37 m (4.5ft ± 0.19–0.33 ft) while coughing. The cloth face covering reduced maximum axial distances to 0.61 m (2.0 ft ± 0.11–0.15 ft) for speech and to 0.67 m (2.2 ft ± 0.02–0.20 ft) while coughing. Using the disposable face covering, safe distance was reduced further to 0.15 m (0.50 ft ± 0.01–0.03 ft) measured for both emission scenarios. In addition, the use of face coverings was highly effective in reducing the count of expelled aerosols. Conclusions The experimental study indicates that 0.914 m (3 ft) physical distancing with face coverings is equally as effective at reducing aerosol/droplet exposure as 1.829 m (6 ft) with no face covering.
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- Award ID(s):
- 2031227
- NSF-PAR ID:
- 10344187
- Date Published:
- Journal Name:
- The Journal of Infectious Diseases
- Volume:
- 225
- Issue:
- 8
- ISSN:
- 0022-1899
- Page Range / eLocation ID:
- 1321 to 1329
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1093/infdis/jiab609
