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1. Decoupled LIGHT-SABRE variants allow hyperpolarization of asymmetric SABRE systems at an arbitrary field

   https://doi.org/10.1016/j.jmr.2019.106577  

   Lindale, Jacob R. ; Tanner, Christian P.N. ; Eriksson, Shannon L. ; Warren, Warren S. ( October 2019 , Journal of Magnetic Resonance)
2. SABRE: The Silicon Array for Branching Ratio Experiments

   https://doi.org/10.1016/j.nima.2021.165299  

   Good, E.C. ; Sudarsan, B. ; Macon, K.T. ; Deibel, C.M. ; Baby, L.T. ; Blackmon, J.C. ; Benetti, C. ; Esparza, J.C. ; Gerken, N. ; Hanselman, K. ; et al ( July 2021 , Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment)
3. Tunable iridium catalyst designs with bidentate N-heterocyclic carbene ligands for SABRE hyperpolarization of sterically hindered substrates

   https://doi.org/10.1039/D0CC06840C  

   Pham, Pierce ; Hilty, Christian ( December 2020 , Chemical Communications)

   A series of bidentate N-heterocyclic carbene (NHC) iridium catalysts, [Ir(κC,N-NHC)H 2 L 2 ]BPh 4 , are proposed for SABRE hyperpolarization. The steric and electronic properties of the NHCs are used to tune substrate affinity and thereby SABRE efficiency. The sterically hindered substrates 2,4-diaminopyrimidine and trimethoprim yielded maximum proton NMR signal enhancements of ∼300-fold and ∼150-fold, respectively.
4. Quantifying the effects of quadrupolar sinks via ¹⁵ N relaxation dynamics in metronidazoles hyperpolarized via SABRE-SHEATH

   https://doi.org/10.1039/D0CC03994B  

   Birchall, Jonathan R. ; Kabir, Mohammad S. ; Salnikov, Oleg G. ; Chukanov, Nikita V. ; Svyatova, Alexandra ; Kovtunov, Kirill V. ; Koptyug, Igor V. ; Gelovani, Juri G. ; Goodson, Boyd M. ; Pham, Wellington ; et al ( January 2020 , Chemical Communications)

   15 N spin–lattice relaxation dynamics in metronidazole- 15 N 3 and metronidazole- 15 N 2 isotopologues are studied for rational design of 15 N-enriched biomolecules for signal amplification by reversible exchange in microtesla fields. 15 N relaxation dynamics mapping reveals the deleterious effects of interactions with the polarization transfer catalyst and a quadrupolar 14 N nucleus within the spin-relayed 15 N– 15 N network.
5. Rational ligand choice extends the SABRE substrate scope

   https://doi.org/10.1039/d0cc01330g  

   Colell, Johannes F. ; Logan, Angus W. ; Zhou, Zijian ; Lindale, Jacob R. ; Laasner, Raul ; Shchepin, Roman V. ; Chekmenev, Eduard Y. ; Blum, Volker ; Warren, Warren S. ; Malcolmson, Steven J. ; et al ( January 2020 , Chemical Communications)

   Here we report on chelating ligands for Signal Amplification By Reversible Exchange (SABRE) catalysts that permit hyperpolarisation on otherwise sterically hindered substrates. We demonstrate 1 H enhancements of ∼100-fold over 8.5 T thermal for 2-substituted pyridines, and smaller, yet significant enhancements for provitamin B 6 and caffeine. We also show 15 N-enhancements of ∼1000-fold and 19 F-enhancements of 30-fold.