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Title: Fidelity of Cotranslational Protein Targeting to the Endoplasmic Reticulum
Fidelity of protein targeting is essential for the proper biogenesis and functioning of organelles. Unlike replication, transcription and translation processes, in which multiple mechanisms to recognize and reject noncognate substrates are established in energetic and molecular detail, the mechanisms by which cells achieve a high fidelity in protein localization remain incompletely understood. Signal recognition particle (SRP), a conserved pathway to mediate the localization of membrane and secretory proteins to the appropriate cellular membrane, provides a paradigm to understand the molecular basis of protein localization in the cell. In this chapter, we review recent progress in deciphering the molecular mechanisms and substrate selection of the mammalian SRP pathway, with an emphasis on the key role of the cotranslational chaperone NAC in preventing protein mistargeting to the ER and in ensuring the organelle specificity of protein localization.  more » « less
Award ID(s):
1929452
PAR ID:
10354898
Author(s) / Creator(s):
;
Date Published:
Journal Name:
International Journal of Molecular Sciences
Volume:
23
Issue:
1
ISSN:
1422-0067
Page Range / eLocation ID:
281
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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